Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 10/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 9/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | AXL | P30530 | 1/20 | 0.37 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.37 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL61008 | 0.79 | ADORA2A (0.49) | ADORA2AADORA1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL20458005 | 0.79 | AXL (0.39) | ADORA2AADORA1SMN1; SMN2RAB9AHTT | |
| SCHEMBL1367259 | 0.78 | AXL (0.52) | ADORA2AADORA1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL24170311 | 0.76 | ADORA2A (0.50) | ADORA2AADORA1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL5334843 | 0.76 | ADORA2A (0.50) | ADORA2AADORA1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL30277827 | 0.76 | ADORA2A (0.50) | ADORA2AADORA1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL24139592 | 0.76 | ADORA2A (0.47) | ADORA2AADORA1SMN1; SMN2RAB9ANPC1 | |
| Hydrochloric Acid SCHEMBL30277817 | 0.74 | ADORA2A (0.49) | ADORA2AADORA1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL10268901 | 0.73 | HTT (0.63) | ADORA2AADORA1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL179279 | 0.73 | ADORA2A (0.44) | ADORA2AADORA1SMN1; SMN2RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3889152-A1 | HETEROAROMATIC DERIVATIVES FOR USE AS REGULATOR, PREPARATION METHOD THEREFOR AND USE THEREOF | Jiangsu Hansoh Pharmaceutical Group Co., Ltd. (CN) | 2021-10-06 | — | — | EP | disclosed |
| WO-2017205762-A1 | INHIBITORS OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE | PHARMACYCLICS LLC (US) | 2017-11-30 | — | — | WO | disclosed |