Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 2/20 | 0.44 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.44 |
| ▸ | TUBB | P07437 | 1/20 | 0.44 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.44 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.44 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.44 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.44 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.44 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.44 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.44 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.44 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.44 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.44 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.44 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.44 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.30 |
| ▸ | MTOR | P42345 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13780007 | 0.79 | KDR (0.46) | KDRTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL18711719 | 0.78 | KDR (0.45) | KDRTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL24175031 | 0.76 | NPY5R (0.46) | KDRTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL10256125 | 0.76 | DYRK1A (0.50) | KDRTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL12736491 | 0.69 | KDR (0.43) | KDRTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL29696570 | 0.69 | PDPK1 (0.40) | KDRTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL24175507 | 0.69 | KDR (0.40) | KDRTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL5925854 | 0.69 | KDR (0.46) | KDRTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL12040846 | 0.68 | ADORA2A (0.42) | KDRDYRK1APIK3CA | |
| SCHEMBL22693058 | 0.65 | KDM4E (0.34) | KDRTUBB4ATUBBTUBA3CTUBA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022002118-A1 | FUSED-RING HETEROCYCLE DERIVATIVE AND MEDICAL USE THEREOF | 四川海思科制药有限公司 | 2022-01-06 | — | — | WO | disclosed |
| WO-2017205762-A1 | INHIBITORS OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE | PHARMACYCLICS LLC (US) | 2017-11-30 | — | — | WO | disclosed |