Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN3 | Q9H6Z9 | 4/20 | 0.55 |
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.46 |
| ▸ | EGLN2 | Q96KS0 | 2/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 10/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1969663 | 0.87 | EGLN1 (0.55) | EGLN3EGLN1EGLN2HIF1A | |
| SCHEMBL1969894 | 0.86 | EGLN1 (0.52) | EGLN3EGLN1EGLN2HIF1A | |
| SCHEMBL1969314 | 0.84 | EGLN3 (0.57) | EGLN3EGLN1EGLN2HIF1AMEN1 | |
| SCHEMBL1968322 | 0.82 | EGLN1 (0.49) | EGLN3EGLN1EGLN2HIF1AKMT2A | |
| SCHEMBL1967663 | 0.81 | EGLN1 (0.51) | EGLN3EGLN1EGLN2HIF1ARXFP1 | |
| SCHEMBL1968936 | 0.80 | EGLN1 (0.52) | EGLN3EGLN1EGLN2HIF1AMEN1 | |
| SCHEMBL1968949 | 0.80 | EGLN1 (0.61) | EGLN3EGLN1MEN1NPC1KMT2A | |
| SCHEMBL1965787 | 0.77 | EGLN1 (0.53) | EGLN3EGLN1EGLN2HIF1AMEN1 | |
| SCHEMBL1964975 | 0.75 | EGLN1 (0.46) | EGLN3EGLN1EGLN2HIF1AMEN1 | |
| SCHEMBL1966325 | 0.75 | EGLN1 (0.49) | EGLN3EGLN1EGLN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2334682-A1 | PYRROLO [ 1, 2 -B] PYRIDAZINE DERIVATIVES AND THEIR USE AS HIF MODULATORS | Fibrogen, Inc. (US) | 2011-06-22 | — | — | EP | claimed |
| WO-2010022240-A1 | PYRROLO [ 1, 2 -B] PYRIDAZINE DERIVATIVES AND THEIR USE AS HIF MODULATORS | FIBROGEN, INC. (US) | 2010-02-25 | — | — | WO | claimed |