Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 19/20 | 0.79 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.63 |
| ▸ | SYK | P43405 | 2/20 | 0.56 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | JAK1 | P23458 | 1/20 | 0.47 |
| ▸ | TYK2 | P29597 | 1/20 | 0.47 |
| ▸ | JAK3 | P52333 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL360683 | 0.90 | IRAK4 (0.78) | IRAK4IRAK1SYKJAK2JAK1 | |
| SCHEMBL359098 | 0.89 | IRAK4 (0.78) | IRAK4IRAK1SYKJAK2JAK1 | |
| SCHEMBL358509 | 0.89 | IRAK4 (0.80) | IRAK4IRAK1SYKJAK2JAK1 | |
| SCHEMBL10254260 | 0.88 | IRAK4 (1.00) | IRAK4IRAK1SYKJAK2JAK1 | |
| SCHEMBL10254225 | 0.88 | IRAK4 (1.00) | IRAK4IRAK1SYKJAK2JAK1 | |
| SCHEMBL358891 | 0.88 | IRAK4 (0.79) | IRAK4IRAK1SYKJAK2JAK1 | |
| SCHEMBL359211 | 0.88 | IRAK4 (0.63) | IRAK4IRAK1SYKJAK2JAK1 | |
| SCHEMBL359403 | 0.85 | IRAK4 (0.68) | IRAK4IRAK1SYKJAK2JAK1 | |
| SCHEMBL359206 | 0.82 | IRAK4 (0.79) | IRAK4IRAK1SYKJAK2JAK1 | |
| SCHEMBL358874 | 0.81 | IRAK4 (0.57) | IRAK4IRAK1SYKJAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3252054-A1 | PYRAZOLO[1,5A]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS | F. Hoffmann-La Roche AG (CH) | 2017-12-06 | — | — | EP | disclosed |