Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.67 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.55 |
| ▸ | SCN4A | P35499 | 4/20 | 0.52 |
| ▸ | SCN8A | Q9UQD0 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.49 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.49 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.49 |
| ▸ | GBA1 | P04062 | 1/20 | 0.49 |
| ▸ | MAOA | P21397 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.49 |
| ▸ | SCN1A | P35498 | 1/20 | 0.49 |
| ▸ | HTR2B | P41595 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19668444 | 1.00 | KCNH2 (0.67) | KCNH2SIGMAR1SCN4ASCN8ALMNA | |
| SCHEMBL19686658 | 0.85 | SCN4A (0.55) | KCNH2SIGMAR1SCN4ASCN8ALMNA | |
| SCHEMBL19668683 | 0.81 | KCNH2 (0.58) | KCNH2SIGMAR1SCN4ASCN8ALMNA | |
| SCHEMBL8819029 | 0.81 | KCNH2 (0.58) | KCNH2SIGMAR1SCN4ASCN8ALMNA | |
| SCHEMBL7699543 | 0.81 | KCNH2 (0.58) | KCNH2LMNANR3C1 | |
| SCHEMBL27687957 | 0.80 | KCNH2 (1.00) | KCNH2LMNASLC6A4HTR2B | |
| Hydrochloric Acid SCHEMBL7701677 | 0.80 | KCNH2 (0.57) | KCNH2NR3C1 | |
| Hydrochloric Acid SCHEMBL27311830 | 0.79 | KCNH2 (0.98) | KCNH2SIGMAR1LMNASLC6A4HTR2B | |
| SCHEMBL19668687 | 0.79 | KCNH2 (0.55) | KCNH2SCN4ASCN8ALMNACYP1A2 | |
| SCHEMBL12994787 | 0.79 | KCNH2 (0.55) | KCNH2SCN4ASCN8ALMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3494105-A2 | COMPOUNDS AS INHIBITORS OF SODIUM CHANNELS | Human Biomolecular Research Institute (US) | 2019-06-12 | — | — | EP | disclosed |
| WO-2017210371-A2 | COMPOUNDS AS INHIBITORS OF SODIUM CHANNELS | HUMAN BIOMOLECULAR RESEARCH INSTITUTE (US) | 2017-12-07 | — | — | WO | disclosed |