Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 2/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.41 |
| ▸ | SLC5A1 | P13866 | 11/20 | 0.40 |
| ▸ | ABL1 | P00519 | 2/20 | 0.40 |
| ▸ | BRAF | P15056 | 3/20 | 0.38 |
| ▸ | KDR | P35968 | 3/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17618450 | 0.91 | PDE4A (0.43) | GSK3BMAPK14PDE4APDE4BPDE4D | |
| SCHEMBL17618440 | 0.89 | ABL1 (0.40) | GSK3BMAPK14PDE4APDE4BPDE4D | |
| SCHEMBL17618470 | 0.89 | ABL1 (0.42) | GSK3BMAPK14PDE4APDE4BPDE4D | |
| SCHEMBL17618471 | 0.88 | MPL (0.45) | GSK3BMAPK14PDE4APDE4BPDE4D | |
| SCHEMBL17618476 | 0.87 | ABL1 (0.39) | GSK3BMAPK14PDE4APDE4BPDE4D | |
| SCHEMBL17618447 | 0.86 | KIT (0.41) | GSK3BMAPK14PDE4APDE4BPDE4D | |
| SCHEMBL17618474 | 0.85 | ABL1 (0.42) | PDE4APDE4BPDE4DSLC5A1ABL1 | |
| SCHEMBL17618478 | 0.85 | IRAK4 (0.42) | GSK3BMAPK14PDE4APDE4BPDE4D | |
| SCHEMBL17618462 | 0.84 | ABL1 (0.41) | PDE4APDE4BPDE4DABL1USP30 | |
| SCHEMBL17618467 | 0.84 | ABL1 (0.47) | PDE4APDE4BPDE4DABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |