Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERBB2 | P04626 | 5/20 | 0.82 |
| ▸ | HSP90AA1 | P07900 | 16/20 | 0.76 |
| ▸ | HSP90AB1 | P08238 | 13/20 | 0.76 |
| ▸ | HSP90B1 | P14625 | 3/20 | 0.65 |
| ▸ | CDC37 | Q16543 | 3/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1963368 | 0.90 | ERBB2 (1.00) | ERBB2HSP90AA1HSP90AB1HSP90B1CDC37 | |
| SCHEMBL1963758 | 0.86 | HSP90AA1 (1.00) | ERBB2HSP90AA1HSP90AB1HSP90B1 | |
| SCHEMBL3130084 | 0.84 | ERBB2 (0.59) | ERBB2HSP90AA1HSP90AB1HSP90B1 | |
| SCHEMBL1964460 | 0.83 | ERBB2 (0.62) | ERBB2HSP90AA1HSP90AB1HSP90B1 | |
| SCHEMBL30583135 | 0.83 | HSP90AA1 (1.00) | ERBB2HSP90AA1HSP90AB1HSP90B1 | |
| SCHEMBL1964321 | 0.83 | HSP90AA1 (1.00) | ERBB2HSP90AA1HSP90AB1HSP90B1 | |
| SCHEMBL14213883 | 0.82 | HSP90AA1 (1.00) | ERBB2HSP90AA1HSP90AB1HSP90B1 | |
| SCHEMBL5038267 | 0.81 | ERBB2 (0.83) | ERBB2HSP90AA1HSP90AB1HSP90B1CDC37 | |
| SCHEMBL14466189 | 0.81 | HSP90AA1 (0.68) | ERBB2HSP90AA1HSP90AB1HSP90B1CDC37 | |
| SCHEMBL1962954 | 0.80 | ERBB2 (0.82) | ERBB2HSP90AA1HSP90AB1HSP90B1CDC37 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4397691-B2 | — | — | 2010-01-13 | — | — | JP | claimed |
| JP-2005511565-A | — | — | 2005-04-28 | — | — | JP | claimed |
| EP-1440072-A4 | PURINE ANALOGS HAVING HSP90-INHIBITING ACTIVITY | CONFORMA THERAPEUTIC CORP (US) | 2005-02-02 | — | — | EP | claimed |
| EP-1440072-A2 | PURINE ANALOGS HAVING HSP90-INHIBITING ACTIVITY | Conforma Therapeutic Corporation (US) | 2004-07-28 | — | — | EP | claimed |
| WO-2003037860-A2 | PURINE ANALOGS HAVING HSP90-INHIBITING ACTIVITY | CONFORMA THERAPEUTICS CORPORATION (US) | 2003-05-08 | — | — | WO | claimed |
| EP-2336133-A1 | Purine analogs having HSP90-inhibiting activity | Conforma Therapeutics Corporation (US) | 2011-06-22 | — | — | EP | disclosed |