Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.50 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.35 |
| ▸ | FLT1 | P17948 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | TEK | Q02763 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12067548 | 1.00 | NPC1 (0.50) | NPC1RAB9AKMT2AMEN1ATM | |
| SCHEMBL2833246 | 0.89 | NPC1 (0.42) | NPC1RAB9AKMT2AMEN1ATM | |
| SCHEMBL2833241 | 0.89 | NPC1 (0.42) | NPC1RAB9AKMT2AMEN1ATM | |
| SCHEMBL12068346 | 0.80 | MAPK1 (0.58) | NPC1RAB9AKMT2AMEN1MAPK1 | |
| SCHEMBL12068348 | 0.80 | MAPK1 (0.58) | NPC1RAB9AKMT2AMEN1MAPK1 | |
| SCHEMBL10779883 | 0.77 | MAPK1 (0.40) | NPC1RAB9AKMT2AMEN1ATM | |
| SCHEMBL1676996 | 0.74 | NPC1 (0.48) | NPC1RAB9AKMT2AMEN1MAPK1 | |
| SCHEMBL1676998 | 0.74 | NPC1 (0.48) | NPC1RAB9AKMT2AMEN1MAPK1 | |
| SCHEMBL1562816 | 0.73 | MEN1 (0.40) | RAB9AKMT2AMEN1MAPK1SMN1; SMN2 | |
| SCHEMBL258654 | 0.73 | MAPK1 (0.41) | NPC1RAB9AKMT2AMEN1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834564-B2 | Substituted quinolines as PDE-10 inhibitors | SUNOVION PHARMACEUTICALS INC. (US) | 2017-12-05 | — | — | US | disclosed |