Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RHOA | P61586 | 1/20 | 0.44 |
| ▸ | BRAF | P15056 | 1/20 | 0.43 |
| ▸ | CREBBP | Q92793 | 3/20 | 0.40 |
| ▸ | BRD4 | O60885 | 2/20 | 0.40 |
| ▸ | FYN | P06241 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CCR3 | P51677 | 1/20 | 0.36 |
| ▸ | CASR | P41180 | 1/20 | 0.35 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21841333 | 0.94 | RHOA (0.45) | RHOABRAFCREBBPBRD4FYN | |
| SCHEMBL19706028 | 0.89 | RHOA (0.36) | RHOABRAFFYNMAPT | |
| SCHEMBL19365667 | 0.88 | RHOA (0.43) | RHOABRAFCREBBPBRD4FYN | |
| SCHEMBL19670564 | 0.87 | RHOA (0.46) | RHOABRAFCREBBPBRD4FYN | |
| SCHEMBL16238774 | 0.86 | RHOA (0.45) | RHOABRAFCREBBPBRD4FYN | |
| SCHEMBL19865057 | 0.84 | RHOA (0.41) | RHOABRAFCREBBPBRD4FYN | |
| SCHEMBL16249983 | 0.83 | RHOA (0.48) | RHOABRAFCREBBPBRD4FYN | |
| SCHEMBL19865069 | 0.83 | RHOA (0.48) | RHOABRAFCREBBPBRD4FYN | |
| SCHEMBL16250011 | 0.83 | RHOA (0.48) | RHOABRAFCREBBPBRD4FYN | |
| SCHEMBL16249975 | 0.83 | RHOA (0.48) | RHOABRAFCREBBPBRD4FYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |