Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | GSK3A | P49840 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | MYLK | Q15746 | 1/20 | 0.32 |
| ▸ | MARK1 | Q9P0L2 | 1/20 | 0.32 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.32 |
| ▸ | FYN | P06241 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | IDH2 | P48735 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365589 | 0.93 | MAPT (0.33) | NPC1RAB9AMEN1KMT2APAX8 | |
| SCHEMBL16785606 | 0.90 | IDH2 (0.40) | MEN1KMT2AIDH2MAPTALDH1A1 | |
| SCHEMBL19365861 | 0.88 | MEN1 (0.34) | MEN1KMT2AIDH2MAPTALDH1A1 | |
| SCHEMBL17624273 | 0.86 | F10 (0.33) | NPC1RAB9AMEN1KMT2APAX8 | |
| SCHEMBL19365411 | 0.86 | IDH2 (0.40) | MEN1KMT2ACYP1A2IDH2MAPT | |
| SCHEMBL17624587 | 0.83 | FGFR4 (0.32) | — | |
| SCHEMBL19670343 | 0.81 | EGFR (0.31) | — | |
| SCHEMBL19670342 | 0.81 | — | — | |
| SCHEMBL17618783 | 0.81 | MEN1 (0.47) | MEN1KMT2AIDH2MAPTALDH1A1 | |
| SCHEMBL16238556 | 0.80 | IDH2 (0.40) | MEN1KMT2AIDH2MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |