Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 14/20 | 0.62 |
| ▸ | TP53 | P04637 | 12/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 10/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 9/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | PKLR | P30613 | 6/20 | 0.52 |
| ▸ | PKM | P14618 | 5/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13031456 | 0.90 | GAA (0.65) | GAATP53SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL1965316 | 0.87 | TP53 (0.58) | GAATP53SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL1965240 | 0.87 | GAA (0.53) | GAATP53SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL13031463 | 0.86 | SMN1; SMN2 (0.76) | GAATP53SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL1967207 | 0.85 | GAA (0.47) | GAATP53SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL13031486 | 0.85 | TP53 (0.70) | GAATP53SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL15152566 | 0.85 | GAA (0.49) | GAATP53SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL1964935 | 0.85 | GAA (0.51) | GAATP53SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL1965194 | 0.82 | GAA (0.79) | GAATP53SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL1968357 | 0.81 | GAA (0.51) | GAATP53SMN1; SMN2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2334675-A1 | IMIDAZOPYRIDINES AND IMIDAZOPYRIMIDINES AS HIV-I REVERSE TRANSCRIPTASE INHIBITORS | CSIR (ZA) | 2011-06-22 | — | — | EP | disclosed |
| WO-2010032195-A1 | IMIDAZOPYRIDINES AND IMIDAZOPYRIMIDINES AS HIV-I REVERSE TRANSCRIPTASE INHIBITORS | CSIR (ZA) | 2010-03-25 | — | — | WO | disclosed |