Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4129380 | 0.88 | IDO1 (0.55) | IDO1RAB9AMEN1KMT2ANPC1 | |
| SCHEMBL28090634 | 0.77 | IDO1 (0.52) | IDO1RAB9AMEN1KMT2ANPC1 | |
| SCHEMBL936605 | 0.73 | IDO1 (0.37) | IDO1RAB9APOLBALOX15TDP1 | |
| SCHEMBL11277042 | 0.73 | IDO1 (0.47) | IDO1RAB9AMEN1KMT2ANPC1 | |
| SCHEMBL6185177 | 0.70 | IDO1 (0.57) | IDO1RAB9AMEN1KMT2ANPC1 | |
| SCHEMBL21808704 | 0.69 | IDO1 (0.61) | IDO1RAB9AMEN1KMT2ANPC1 | |
| SCHEMBL11118464 | 0.66 | IDO1 (0.57) | IDO1RAB9AMEN1KMT2ANPC1 | |
| SCHEMBL11502327 | 0.66 | IDO1 (0.57) | IDO1RAB9AMEN1KMT2ANPC1 | |
| SCHEMBL16711400 | 0.66 | IDO1 (0.57) | IDO1RAB9AMEN1KMT2ANPC1 | |
| SCHEMBL1754221 | 0.66 | IDO1 (0.57) | IDO1RAB9AMEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3252049-A1 | PHTHALAZINONES AND ISOQUINOLINONES AS ROCK INHIBITORS | Bristol-Myers Squibb Company (US) | 2017-12-06 | — | — | EP | disclosed |
| EP-3252050-A1 | PHTHALAZINONES AND ISOQUINOLINONES AS ROCK INHIBITORS | Bristol-Myers Squibb Company (US) | 2017-12-06 | — | — | EP | disclosed |