Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 3/20 | 0.67 |
| ▸ | TBK1 | Q9UHD2 | 3/20 | 0.36 |
| ▸ | JAK2 | O60674 | 2/20 | 0.36 |
| ▸ | JAK3 | P52333 | 2/20 | 0.36 |
| ▸ | FLT1 | P17948 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | FLT4 | P35916 | 1/20 | 0.36 |
| ▸ | BLK | P51451 | 1/20 | 0.36 |
| ▸ | ITK | Q08881 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 3/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.34 |
| ▸ | MERTK | Q12866 | 1/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 2/20 | 0.34 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.33 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.33 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16450121 | 0.93 | FLT3 (0.68) | FLT3TBK1JAK2JAK3FLT1 | |
| SCHEMBL15584736 | 0.91 | FLT3 (0.70) | FLT3TBK1JAK2JAK3FLT1 | |
| SCHEMBL17969617 | 0.91 | FLT3 (0.70) | FLT3TBK1JAK2JAK3FLT1 | |
| SCHEMBL15585805 | 0.91 | FLT3 (0.70) | FLT3TBK1JAK2JAK3FLT1 | |
| SCHEMBL15585824 | 0.88 | FLT3 (0.67) | FLT3TBK1JAK2JAK3FLT1 | |
| SCHEMBL15585827 | 0.88 | FLT3 (0.67) | FLT3TBK1JAK2JAK3FLT1 | |
| SCHEMBL19102809 | 0.87 | FLT3 (0.76) | FLT3TBK1JAK2JAK3FLT1 | |
| SCHEMBL15585091 | 0.86 | FLT3 (0.65) | FLT3TBK1JAK2JAK3FLT1 | |
| SCHEMBL19675986 | 0.86 | FLT3 (0.65) | FLT3TBK1JAK2JAK3FLT1 | |
| SCHEMBL17969608 | 0.85 | FLT3 (0.80) | FLT3TBK1JAK2JAK3FLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2840080-B1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUND OR SALT THEREOF | FUJIFILM CORP (JP) | 2017-12-06 | — | — | EP | disclosed |