Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 7/20 | 0.43 |
| ▸ | KDM5C | P41229 | 5/20 | 0.43 |
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.40 |
| ▸ | KDM5B | Q9UGL1 | 9/20 | 0.40 |
| ▸ | KDM5A | P29375 | 5/20 | 0.40 |
| ▸ | KDM6B | O15054 | 3/20 | 0.40 |
| ▸ | KDM4A | O75164 | 2/20 | 0.40 |
| ▸ | PROKR1 | Q8TCW9 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.37 |
| ▸ | KDM3A | Q9Y4C1 | 2/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19676391 | 0.91 | KDM5C (0.41) | KDM4CKDM5CKDM2BKDM5BKDM5A | |
| SCHEMBL15637391 | 0.90 | KDM4C (0.44) | KDM4CKDM5CKDM2BKDM5BKDM5A | |
| SCHEMBL16291490 | 0.81 | HRH3 (0.45) | KDM4CKDM5CKDM2BKDM5BKDM5A | |
| SCHEMBL16291875 | 0.80 | KDM5C (0.43) | KDM4CKDM5CKDM2BKDM5BKDM5A | |
| SCHEMBL15637002 | 0.78 | KDM4C (0.41) | KDM4CKDM5CKDM2BKDM5BKDM5A | |
| SCHEMBL15636756 | 0.78 | PIK3CA (0.45) | KDM4CKDM5CKDM5BKDM5A | |
| SCHEMBL16291657 | 0.77 | DPP7 (0.42) | KDM4CKDM5CKDM2BKDM5BKDM5A | |
| SCHEMBL16291664 | 0.76 | KDM4C (0.43) | KDM4CKDM5CKDM2BKDM5BKDM5A | |
| SCHEMBL19741729 | 0.75 | KDM4C (0.41) | KDM4CKDM5CKDM2BKDM5BKDM5A | |
| SCHEMBL19676439 | 0.74 | KDM4C (0.39) | KDM4CKDM5CKDM2BKDM5BKDM5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3023415-B1 | INHIBITORS OF HISTONE DEMETHYLASES | GILEAD SCIENCES INC (US) | 2017-12-06 | — | — | EP | disclosed |