Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | ECE2 | P0DPD6 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 5/20 | 0.37 |
| ▸ | NPC1 | O15118 | 5/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | HPGD | P15428 | 4/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16291490 | 0.86 | HRH3 (0.45) | HRH3KDM4E | |
| SCHEMBL16291875 | 0.80 | KDM5C (0.43) | HRH3SMN1; SMN2HPGDALDH1A1MEN1 | |
| SCHEMBL15637391 | 0.76 | KDM4C (0.44) | RAB9ANPC1SMN1; SMN2HPGDKDM4E | |
| SCHEMBL19676391 | 0.76 | KDM5C (0.41) | HRH3HPGDALDH1A1KDM4E | |
| SCHEMBL19741729 | 0.73 | KDM4C (0.41) | HDAC1HDAC6RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL15636756 | 0.73 | PIK3CA (0.45) | RAB9ANPC1SMN1; SMN2HPGDGAA | |
| SCHEMBL16291657 | 0.72 | DPP7 (0.42) | NPC1 | |
| SCHEMBL16922675 | 0.72 | KMT2A (0.42) | HTTHDAC1HDAC6RAB9ANPC1 | |
| SCHEMBL15637002 | 0.72 | KDM4C (0.41) | RAB9ANPC1SMN1; SMN2HPGDMEN1 | |
| SCHEMBL17144208 | 0.71 | SMN1; SMN2 (0.41) | HTTRAB9ANPC1SMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3023415-B1 | INHIBITORS OF HISTONE DEMETHYLASES | GILEAD SCIENCES INC (US) | 2017-12-06 | — | — | EP | disclosed |