Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.42 |
| ▸ | KDM5B | Q9UGL1 | 5/20 | 0.42 |
| ▸ | KDM5C | P41229 | 3/20 | 0.42 |
| ▸ | KDM4A | O75164 | 2/20 | 0.42 |
| ▸ | KDM5A | P29375 | 2/20 | 0.42 |
| ▸ | KDM6B | O15054 | 1/20 | 0.42 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 3/20 | 0.40 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.40 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16291439 | 0.90 | HRH3 (0.46) | KDM2BKDM5BKDM5CKDM4AKDM5A | |
| SCHEMBL16310721 | 0.90 | HRH3 (0.46) | KDM2BKDM5BKDM5CKDM4AKDM5A | |
| SCHEMBL16291521 | 0.86 | KDM5B (0.44) | KDM2BKDM5BKDM5CKDM4AKDM5A | |
| SCHEMBL15637611 | 0.83 | DPP4 (0.47) | KDM2BKDM5BKDM5CKDM4AKDM5A | |
| SCHEMBL15636442 | 0.78 | KDM5B (0.52) | KDM2BKDM5BKDM5CKDM4AKDM5A | |
| SCHEMBL16293429 | 0.77 | HRH3 (0.47) | — | |
| SCHEMBL16006922 | 0.77 | HRH3 (0.43) | — | |
| SCHEMBL19676422 | 0.77 | KDM4C (0.42) | KDM5CKDM4CDPP4DPP8DPP9 | |
| SCHEMBL15637693 | 0.76 | KDM2B (0.51) | KDM2BKDM5BKDM5CKDM4AKDM5A | |
| SCHEMBL15636566 | 0.74 | KDM2B (0.49) | KDM2BKDM5BKDM5CKDM4AKDM5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3023415-B1 | INHIBITORS OF HISTONE DEMETHYLASES | GILEAD SCIENCES INC (US) | 2017-12-06 | — | — | EP | disclosed |