Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5B | Q9UGL1 | 17/20 | 0.67 |
| ▸ | KDM5C | P41229 | 11/20 | 0.67 |
| ▸ | KDM5A | P29375 | 8/20 | 0.67 |
| ▸ | KDM4A | O75164 | 4/20 | 0.67 |
| ▸ | KDM6B | O15054 | 1/20 | 0.67 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.67 |
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.56 |
| ▸ | KDM5D | Q9BY66 | 1/20 | 0.56 |
| ▸ | KDM4B | O94953 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GABRP | O00591 | 1/20 | 0.38 |
| ▸ | GABRD | O14764 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15636865 | 0.88 | KDM5B (0.64) | KDM5BKDM5CKDM5AKDM4AKDM6B | |
| SCHEMBL15636266 | 0.87 | KDM5B (0.74) | KDM5BKDM5CKDM5AKDM4AKDM6B | |
| SCHEMBL17772487 | 0.81 | KDM5B (0.58) | KDM5BKDM5CKDM5AKDM4AKDM6B | |
| SCHEMBL15636679 | 0.80 | KDM5B (1.00) | KDM5BKDM5CKDM5AKDM4AKDM6B | |
| SCHEMBL15638915 | 0.79 | KDM5B (0.56) | KDM5BKDM5CKDM5AKDM4AKDM6B | |
| SCHEMBL18708410 | 0.78 | KDM5B (0.55) | KDM5BKDM5CKDM5AKDM4AKDM6B | |
| SCHEMBL15639854 | 0.78 | KDM5B (0.57) | KDM5BKDM5CKDM5AKDM4AKDM6B | |
| SCHEMBL15636244 | 0.77 | KDM5B (0.68) | KDM5BKDM5CKDM5AKDM4AKDM6B | |
| SCHEMBL15636990 | 0.76 | KDM5B (0.60) | KDM5BKDM5CKDM5AKDM4AKDM6B | |
| SCHEMBL19676453 | 0.76 | KDM5B (0.65) | KDM5BKDM5CKDM5AKDM4AKDM6B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3023415-B1 | INHIBITORS OF HISTONE DEMETHYLASES | GILEAD SCIENCES INC (US) | 2017-12-06 | — | — | EP | disclosed |