SCHEMBL19683533

SCHEMBL19683533

c1ccc(N(c2ccccc2)c2ccc(-c3cc4cc5cc6oc(-c7ccc(N(c8ccccc8)c8ccccc8)cc7)cc6cc5cc4o3)cc2)cc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 3/20 0.46
APP P05067 3/20 0.44
ESR1 P03372 1/20 0.41
ESR2 Q92731 1/20 0.41
SHBG P04278 1/20 0.41
L3MBTL1 Q9Y468 2/20 0.40
TNKS O95271 1/20 0.40
HDAC6 Q9UBN7 1/20 0.39
CA1 P00915 1/20 0.39
CA2 P00918 1/20 0.39
CA9 Q16790 1/20 0.39
FFAR1 O14842 1/20 0.38
PLA2G2A P14555 2/20 0.38
PLA2G4A P47712 2/20 0.38
ALOX5 P09917 1/20 0.38
HIF1A Q16665 1/20 0.37
KDM4E B2RXH2 1/20 0.37
ALDH1A1 P00352 1/20 0.37
CYP1A2 P05177 1/20 0.37
CYP3A4 P08684 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14900871 0.97 MAOB (0.49) MAOBAPPESR1ESR2SHBG
SCHEMBL18590858 0.95 MAOB (0.47) MAOBAPPESR1ESR2SHBG
SCHEMBL19683537 0.94 MAOB (0.54) MAOBAPPESR1ESR2SHBG
SCHEMBL24368895 0.92 MAOB (0.49) MAOBAPPESR1ESR2SHBG
SCHEMBL14900889 0.92 MAOB (0.51) MAOBAPPESR1ESR2SHBG
SCHEMBL24368621 0.90 MAOB (0.47) MAOBAPPESR1ESR2SHBG
SCHEMBL24368565 0.90 MAOB (0.47) MAOBAPPESR1ESR2SHBG
SCHEMBL24368561 0.90 MAOB (0.47) MAOBAPPESR1ESR2SHBG
SCHEMBL24368556 0.90 MAOB (0.47) MAOBAPPESR1ESR2SHBG
SCHEMBL24368894 0.90 MAOB (0.47) MAOBAPPESR1ESR2SHBG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2017210072-A1 ELECTROACTIVE COMPOUNDS E. I. DU PONT DE NEMOURS AND COMPANY (US) 2017-12-07 WO disclosed