Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 8/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 7/20 | 0.40 |
| ▸ | FLT3 | P36888 | 5/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 2/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | INSR | P06213 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | FYN | P06241 | 1/20 | 0.37 |
| ▸ | YES1 | P07947 | 1/20 | 0.37 |
| ▸ | LYN | P07948 | 1/20 | 0.37 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
| ▸ | ROS1 | P08922 | 1/20 | 0.37 |
| ▸ | KIT | P10721 | 1/20 | 0.37 |
| ▸ | BCR | P11274 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19683644 | 0.92 | FLT3 (0.41) | BRAFEGFRRETFLT3CSF1R | |
| SCHEMBL20878996 | 0.92 | RET (0.41) | BRAFEGFRRETFLT3CSF1R | |
| SCHEMBL20878953 | 0.88 | FLT3 (0.50) | BRAFEGFRRETFLT3CSF1R | |
| SCHEMBL20878898 | 0.85 | RET (0.52) | BRAFRETFLT3CSF1RKDR | |
| SCHEMBL19683701 | 0.83 | FLT3 (0.44) | BRAFEGFRRETFLT3CSF1R | |
| SCHEMBL20878980 | 0.83 | FLT3 (0.53) | BRAFRETFLT3CSF1RKDR | |
| SCHEMBL23047310 | 0.82 | RET (0.41) | BRAFRETFLT3CSF1RKDR | |
| SCHEMBL19683697 | 0.82 | RET (0.44) | BRAFRETFLT3CSF1RKDR | |
| SCHEMBL19683754 | 0.82 | RET (0.52) | BRAFRETFLT3CSF1RKDR | |
| SCHEMBL23047345 | 0.82 | RET (0.46) | BRAFRETFLT3CSF1RKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3466952-A1 | NOVEL INHIBITOR FOR FLT3 KINASE AND USES THEREOF | Precedo Pharmaceuticals Co., Ltd. (CN) | 2019-04-10 | — | — | EP | disclosed |
| WO-2017206962-A1 | NOVEL INHIBITOR FOR FLT3 KINASE AND USES THEREOF | 合肥中科普瑞昇生物医药科技有限公司 | 2017-12-07 | — | — | WO | disclosed |