Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.50 |
| ▸ | RAB9A | P51151 | 8/20 | 0.49 |
| ▸ | NPC1 | O15118 | 7/20 | 0.49 |
| ▸ | CASP1 | P29466 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | HPGD | P15428 | 5/20 | 0.44 |
| ▸ | TSHR | P16473 | 4/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.41 |
| ▸ | RELA | Q04206 | 2/20 | 0.41 |
| ▸ | STAT1 | P42224 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1966568 | 0.74 | NR1H2 (0.39) | SMN1; SMN2RAB9ANPC1ALDH1A1TSHR | |
| SCHEMBL31077570 | 0.71 | MAPT (0.38) | SMN1; SMN2CYP1A2CYP2C19RAB9ANPC1 | |
| SCHEMBL29225364 | 0.71 | CNR1 (0.42) | SMN1; SMN2RAB9ANPC1ALDH1A1HPGD | |
| SCHEMBL14791071 | 0.70 | MAPT (0.37) | SMN1; SMN2RAB9ANPC1ALDH1A1HPGD | |
| SCHEMBL9920358 | 0.70 | TSHR (0.38) | SMN1; SMN2CYP1A2RAB9ANPC1ALDH1A1 | |
| SCHEMBL9807560 | 0.70 | CNR1 (0.47) | SMN1; SMN2RAB9ANPC1ALDH1A1HPGD | |
| SCHEMBL2451961 | 0.69 | CNR1 (0.46) | CYP1A2CYP2C19ALDH1A1TSHRTDP1 | |
| SCHEMBL28905637 | 0.69 | TSHR (0.40) | SMN1; SMN2CYP1A2CYP2C19RAB9ANPC1 | |
| SCHEMBL9980549 | 0.68 | MAPT (0.33) | SMN1; SMN2RAB9ANPC1ALDH1A1HPGD | |
| SCHEMBL5863101 | 0.68 | TSHR (0.38) | SMN1; SMN2CYP1A2RAB9AALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2334682-A1 | PYRROLO [ 1, 2 -B] PYRIDAZINE DERIVATIVES AND THEIR USE AS HIF MODULATORS | Fibrogen, Inc. (US) | 2011-06-22 | — | — | EP | disclosed |
| WO-2010022240-A1 | PYRROLO [ 1, 2 -B] PYRIDAZINE DERIVATIVES AND THEIR USE AS HIF MODULATORS | FIBROGEN, INC. (US) | 2010-02-25 | — | — | WO | disclosed |