Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 2/20 | 0.32 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.31 |
| ▸ | CCNC | P24863 | 1/20 | 0.31 |
| ▸ | CDK8 | P49336 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20645 | 0.93 | GRM4 (0.32) | GRM4CCNCCDK8 | |
| SCHEMBL15006953 | 0.93 | CHEK1 (0.32) | GRM4CCNCCDK8 | |
| SCHEMBL20512 | 0.93 | GRM4 (0.32) | GRM4DGAT1CCNCCDK8 | |
| SCHEMBL19940 | 0.93 | GRM4 (0.32) | GRM4CCNCCDK8 | |
| SCHEMBL15007518 | 0.93 | GRM4 (0.31) | GRM4DGAT1CCNCCDK8 | |
| SCHEMBL15026296 | 0.92 | GRM4 (0.31) | GRM4 | |
| SCHEMBL19473 | 0.92 | CHEK1 (0.32) | GRM4 | |
| SCHEMBL43136 | 0.91 | CCNC (0.31) | CCNCCDK8 | |
| SCHEMBL29175 | 0.89 | CCNC (0.31) | GRM4CCNCCDK8 | |
| SCHEMBL21518 | 0.88 | GRM4 (0.32) | GRM4DGAT1CCNCCDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2608669-B1 | NOVEL PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS | MERCK SHARP & DOHME (US) | 2016-06-22 | — | — | EP | disclosed |
| WO-2012027236-A1 | NOVEL PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS | SCHERING CORPORATION (US) | 2012-03-01 | — | — | WO | disclosed |