Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCDIN3D | Q7Z5W3 | 1/20 | 0.34 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.34 |
| ▸ | BUB1 | O43683 | 1/20 | 0.33 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.32 |
| ▸ | TYRO3 | Q06418 | 4/20 | 0.32 |
| ▸ | AXL | P30530 | 2/20 | 0.32 |
| ▸ | MERTK | Q12866 | 2/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.31 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.31 |
| ▸ | SELP | P16109 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29717657 | 0.86 | GRM4 (0.31) | GRM4 | |
| SCHEMBL19685543 | 0.85 | GRM5 (0.39) | HDAC3HDAC1HDAC2HDAC6CYP3A4 | |
| SCHEMBL19685710 | 0.77 | DYRK1A (0.36) | HDAC3HDAC1HDAC2HDAC6CYP3A4 | |
| SCHEMBL29717707 | 0.77 | LATS1 (0.39) | — | |
| SCHEMBL19689004 | 0.76 | GRM5 (0.42) | HDAC3HDAC1HDAC2HDAC6CYP3A4 | |
| SCHEMBL19685999 | 0.76 | GRM5 (0.42) | HDAC3HDAC1HDAC2HDAC6CYP3A4 | |
| SCHEMBL19665698 | 0.75 | MAPK8 (0.46) | MAPK1 | |
| SCHEMBL29802855 | 0.75 | MAPK8 (0.46) | MAPK1 | |
| SCHEMBL21385847 | 0.74 | MAPK8 (0.46) | MAPK1 | |
| SCHEMBL19666607 | 0.72 | MAPK8 (0.44) | MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017210408-A1 | ANIMAL AND HUMAN ANTI-TRYPANOSOMONAL AND ANTI-LEISHMANIA AGENTS | CELGENE CORPORATION (US) | 2017-12-07 | — | — | WO | disclosed |