Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 13/20 | 0.39 |
| ▸ | IDH2 | P48735 | 2/20 | 0.37 |
| ▸ | KCNN2 | Q9H2S1 | 1/20 | 0.35 |
| ▸ | KCNN3 | Q9UGI6 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19686365 | 0.87 | IDH1 (0.48) | IDH1IDH2KCNN2KCNN3SMN1; SMN2 | |
| SCHEMBL21165874 | 0.85 | IDH1 (0.40) | IDH1IDH2KCNN2KCNN3SMN1; SMN2 | |
| SCHEMBL19687311 | 0.84 | IDH1 (0.39) | IDH1IDH2KCNN2KCNN3SMN1; SMN2 | |
| SCHEMBL31127245 | 0.84 | IDH1 (0.42) | IDH1IDH2KCNN2KCNN3SMN1; SMN2 | |
| SCHEMBL21143969 | 0.84 | IDH1 (0.42) | IDH1IDH2KCNN2KCNN3SMN1; SMN2 | |
| SCHEMBL19686984 | 0.83 | IDH1 (0.46) | IDH1IDH2KCNN2KCNN3SMN1; SMN2 | |
| SCHEMBL31127339 | 0.83 | IDH1 (0.46) | IDH1IDH2KCNN2KCNN3SMN1; SMN2 | |
| SCHEMBL19687385 | 0.82 | IDH1 (0.47) | IDH1IDH2SMN1; SMN2LMNAGAA | |
| SCHEMBL19687333 | 0.82 | SMN1; SMN2 (0.53) | IDH1IDH2SMN1; SMN2LMNAGAA | |
| SCHEMBL19686357 | 0.81 | IDH1 (0.40) | IDH1IDH2KCNN2KCNN3SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017139697-A9 | BACTERIA ENGINEERED TO TREAT DISEASES ASSOCIATED WITH HYPERAMMONEMIA | SYNLOGIC, INC. (US) | 2017-12-07 | — | — | WO | disclosed |