Sugi Predict

Sugi Predict / Compounds / SCHEMBL19686524

SCHEMBL19686524

SCHEMBL19686524

Cc1cc(C)n(-c2nc(NC3CCC(F)(F)CC3)cc(C(N)=O)n2)n1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KCNN2 Q9H2S1 1/20 0.54
▸ KCNN3 Q9UGI6 1/20 0.54
▸ ADORA2A P29274 14/20 0.41
▸ ADORA1 P30542 11/20 0.41
▸ SYK P43405 1/20 0.40
▸ NR2F2 P24468 2/20 0.39
▸ NPSR1 Q6W5P4 2/20 0.39
▸ KDM4E B2RXH2 1/20 0.39
▸ MAPT P10636 1/20 0.39
▸ MAPK1 P28482 1/20 0.39
▸ ALOX15 P16050 1/20 0.39
▸ MEN1 O00255 1/20 0.39
▸ NPC1 O15118 1/20 0.39
▸ S1PR2 O95136 1/20 0.39
▸ ALDH1A1 P00352 1/20 0.39
▸ LMNA P02545 1/20 0.39
▸ XBP1 P17861 1/20 0.39
▸ RAB9A P51151 1/20 0.39
▸ PPP1CA P62136 1/20 0.39
▸ KMT2A Q03164 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19686309 0.94 KCNN2 (0.49) KCNN2KCNN3ADORA2AADORA1SYK
SCHEMBL31127221 0.92 KCNN2 (0.56) KCNN2KCNN3ADORA2AADORA1NR2F2
SCHEMBL19687084 0.92 KCNN2 (0.56) KCNN2KCNN3ADORA2AADORA1NR2F2
SCHEMBL21143851 0.91 KCNN2 (0.55) KCNN2KCNN3ADORA2AADORA1NR2F2
SCHEMBL19687168 0.89 KCNN2 (0.53) KCNN2KCNN3ADORA2AADORA1NR2F2
SCHEMBL19686500 0.88 KCNN2 (0.53) KCNN2KCNN3ADORA2AADORA1NR2F2
SCHEMBL21143898 0.88 KCNN2 (0.56) KCNN2KCNN3ADORA2AADORA1NPSR1
SCHEMBL31127097 0.88 KCNN2 (0.56) KCNN2KCNN3ADORA2AADORA1NPSR1
SCHEMBL21143905 0.86 NPSR1 (0.52) KCNN2KCNN3ADORA2AADORA1NR2F2
SCHEMBL19687217 0.85 KCNN2 (0.51) KCNN2KCNN3ADORA2AADORA1NR2F2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240317705-A1 POTASSIUM CHANNEL MODULATORS NOVARTIS AG (CH) 2024-09-26 — — US disclosed
US-10774064-B2 Potassium channel modulators CADENT THERAPEUTICS, INC. (US) 2020-09-15 — — US disclosed
US-10774064-B2 Potassium channel modulators CADENT THERAPEUTICS, INC. (US) 2020-09-15 — — US disclosed
US-20190218200-A1 POTASSIUM CHANNEL MODULATORS NOVARTIS AG (CH) 2019-07-18 — — US disclosed
US-20190218200-A1 POTASSIUM CHANNEL MODULATORS NOVARTIS AG (CH) 2019-07-18 — — US disclosed
WO-2017139697-A9 BACTERIA ENGINEERED TO TREAT DISEASES ASSOCIATED WITH HYPERAMMONEMIA SYNLOGIC, INC. (US) 2017-12-07 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240317705-A1 POTASSIUM CHANNEL MODULATORS KCNJ11, KCNJ2, KCNJ1 KCNN2 5/4885KCNN3 11/4885ADORA2A 1711/4885
US-10774064-B2 Potassium channel modulators KCNJ11, KCNJ2, KCNJ1 KCNN2 5/4885KCNN3 11/4885ADORA2A 1711/4885
US-20190218200-A1 POTASSIUM CHANNEL MODULATORS KCNJ11, KCNJ2, KCNJ1 KCNN2 5/4885KCNN3 11/4885ADORA2A 1711/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.