Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 8/20 | 0.39 |
| ▸ | IDH2 | P48735 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.32 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.32 |
| ▸ | TPH1 | P17752 | 3/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19686538 | 0.87 | IDH1 (0.38) | IDH1IDH2SYKTPH1 | |
| SCHEMBL31127133 | 0.87 | IDH1 (0.38) | IDH1IDH2SYKTPH1 | |
| SCHEMBL21144161 | 0.82 | IDH1 (0.40) | IDH1IDH2TPH1 | |
| SCHEMBL31127074 | 0.81 | IDH1 (0.41) | IDH1IDH2SYKGPR119DDB1 | |
| SCHEMBL19687490 | 0.81 | IDH1 (0.41) | IDH1IDH2SYKGPR119DDB1 | |
| SCHEMBL21143643 | 0.80 | IDH1 (0.48) | IDH1IDH2SYKGPR119DDB1 | |
| SCHEMBL19686290 | 0.80 | IDH1 (0.42) | IDH1IDH2 | |
| SCHEMBL19686817 | 0.80 | IDH1 (0.45) | IDH1IDH2 | |
| SCHEMBL19686816 | 0.79 | IDH1 (0.43) | IDH1IDH2 | |
| SCHEMBL24061661 | 0.78 | CHRM3 (0.46) | IDH1IDH2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017139697-A9 | BACTERIA ENGINEERED TO TREAT DISEASES ASSOCIATED WITH HYPERAMMONEMIA | SYNLOGIC, INC. (US) | 2017-12-07 | — | — | WO | disclosed |