Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 15/20 | 0.39 |
| ▸ | IDH2 | P48735 | 2/20 | 0.34 |
| ▸ | BCL9 | O00512 | 2/20 | 0.32 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.32 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.32 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | CCND3 | P30281 | 1/20 | 0.32 |
| ▸ | CDK7 | P50613 | 1/20 | 0.32 |
| ▸ | CDK9 | P50750 | 1/20 | 0.32 |
| ▸ | CCNH | P51946 | 1/20 | 0.32 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.32 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.32 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.32 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.32 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19687438 | 0.85 | IDH1 (0.40) | IDH1IDH2 | |
| Hydrochloric Acid SCHEMBL21143718 | 0.84 | IDH1 (0.39) | IDH1IDH2 | |
| Hydrochloric Acid SCHEMBL31127043 | 0.84 | IDH1 (0.39) | IDH1IDH2 | |
| SCHEMBL21166022 | 0.83 | IDH1 (0.38) | IDH1IDH2 | |
| SCHEMBL19686905 | 0.82 | IDH1 (0.37) | IDH1IDH2 | |
| SCHEMBL19686539 | 0.81 | IDH1 (0.42) | IDH1IDH2 | |
| SCHEMBL19686904 | 0.81 | IDH1 (0.41) | IDH1IDH2 | |
| SCHEMBL19686908 | 0.80 | IDH1 (0.38) | IDH1IDH2 | |
| SCHEMBL19686562 | 0.80 | IDH1 (0.36) | IDH1IDH2 | |
| SCHEMBL19686830 | 0.80 | IDH1 (0.41) | IDH1IDH2CCNT1CCNA2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017139697-A9 | BACTERIA ENGINEERED TO TREAT DISEASES ASSOCIATED WITH HYPERAMMONEMIA | SYNLOGIC, INC. (US) | 2017-12-07 | — | — | WO | disclosed |