Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 7/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 6/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.33 |
| ▸ | IDH2 | P48735 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | DRD4 | P21917 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | CCNK | O75909 | 1/20 | 0.30 |
| ▸ | CDK9 | P50750 | 1/20 | 0.30 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19687013 | 1.00 | IDH1 (0.36) | IDH1LRRK2IRAK4ADORA2AADORA1 | |
| SCHEMBL19687017 | 1.00 | IDH1 (0.36) | IDH1LRRK2IRAK4ADORA2AADORA1 | |
| SCHEMBL19687070 | 0.92 | IDH1 (0.36) | IDH1IDH2DRD4SIGMAR1 | |
| SCHEMBL19686474 | 0.91 | IDH1 (0.38) | IDH1IRAK4ADORA2AIDH2 | |
| SCHEMBL19687081 | 0.90 | IDH1 (0.37) | IDH1LRRK2IRAK4IDH2 | |
| SCHEMBL19686991 | 0.90 | HRH4 (0.38) | LRRK2IRAK4ADORA2AADORA1 | |
| SCHEMBL19686987 | 0.90 | HRH4 (0.38) | LRRK2IRAK4ADORA2AADORA1 | |
| SCHEMBL19686990 | 0.90 | HRH4 (0.38) | LRRK2IRAK4ADORA2AADORA1 | |
| SCHEMBL19687069 | 0.88 | IDH1 (0.36) | IDH1IRAK4IDH2 | |
| SCHEMBL21165919 | 0.86 | SYK (0.36) | IDH1LRRK2IRAK4IDH2SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10774064-B2 | Potassium channel modulators | CADENT THERAPEUTICS, INC. (US) | 2020-09-15 | — | — | US | disclosed |
| US-20190218200-A1 | POTASSIUM CHANNEL MODULATORS | NOVARTIS AG (CH) | 2019-07-18 | — | — | US | disclosed |
| WO-2017139697-A9 | BACTERIA ENGINEERED TO TREAT DISEASES ASSOCIATED WITH HYPERAMMONEMIA | SYNLOGIC, INC. (US) | 2017-12-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10774064-B2 | Potassium channel modulators | KCNJ11, KCNJ2, KCNJ1 | IDH1 3017/4885LRRK2 1193/4885IRAK4 1952/4885 |
| US-20190218200-A1 | POTASSIUM CHANNEL MODULATORS | KCNJ11, KCNJ2, KCNJ1 | IDH1 3017/4885LRRK2 1193/4885IRAK4 1952/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.