Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 9/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | IDH1 | O75874 | 4/20 | 0.48 |
| ▸ | GBA1 | P04062 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | ABCC1 | P33527 | 6/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
| ▸ | LCK | P06239 | 1/20 | 0.45 |
| ▸ | FYN | P06241 | 1/20 | 0.45 |
| ▸ | IGF1R | P08069 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19686519 | 0.82 | IDH1 (0.72) | LMNAMEN1KMT2ATDP1IDH1 | |
| SCHEMBL16391863 | 0.80 | GBA1 (0.48) | ABCG2MEN1KMT2AIDH1GBA1 | |
| SCHEMBL19686326 | 0.80 | IDH1 (0.71) | LMNAMEN1KMT2ATDP1IDH1 | |
| SCHEMBL21165927 | 0.79 | IDH1 (0.45) | LMNAMEN1KMT2ATDP1IDH1 | |
| SCHEMBL23813325 | 0.78 | IDH1 (0.58) | IDH1GBA1 | |
| SCHEMBL19686301 | 0.78 | IDH1 (0.56) | LMNAMEN1KMT2ATDP1IDH1 | |
| SCHEMBL19686970 | 0.78 | IDH1 (0.45) | LMNAMEN1KMT2ATDP1IDH1 | |
| SCHEMBL19686338 | 0.78 | IDH1 (0.51) | LMNAMEN1KMT2ATDP1IDH1 | |
| SCHEMBL19686518 | 0.77 | IDH1 (0.45) | LMNAMEN1KMT2ATDP1IDH1 | |
| SCHEMBL31127196 | 0.77 | IDH1 (0.43) | LMNAMEN1KMT2ATDP1IDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017139697-A9 | BACTERIA ENGINEERED TO TREAT DISEASES ASSOCIATED WITH HYPERAMMONEMIA | SYNLOGIC, INC. (US) | 2017-12-07 | — | — | WO | disclosed |