Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 11/20 | 0.38 |
| ▸ | IDH2 | P48735 | 3/20 | 0.34 |
| ▸ | CACNA1G | O43497 | 3/20 | 0.32 |
| ▸ | CACNA1H | O95180 | 3/20 | 0.32 |
| ▸ | CACNA1I | Q9P0X4 | 3/20 | 0.32 |
| ▸ | NOS1 | P29475 | 1/20 | 0.32 |
| ▸ | NOS2 | P35228 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | CACNB4 | O00305 | 2/20 | 0.31 |
| ▸ | CACNA1A | O00555 | 2/20 | 0.31 |
| ▸ | CACNG3 | O60359 | 2/20 | 0.31 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.31 |
| ▸ | CACNB3 | P54284 | 2/20 | 0.31 |
| ▸ | CACNA2D1 | P54289 | 2/20 | 0.31 |
| ▸ | CACNG7 | P62955 | 2/20 | 0.31 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.31 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.31 |
| ▸ | CACNB1 | Q02641 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31127199 | 0.91 | IDH1 (0.39) | IDH1IDH2NOS1NOS2PDE4D | |
| SCHEMBL19687001 | 0.91 | IDH1 (0.39) | IDH1IDH2NOS1NOS2PDE4D | |
| SCHEMBL19686287 | 0.91 | IDH1 (0.39) | IDH1IDH2NOS1NOS2PDE4D | |
| SCHEMBL19687003 | 0.90 | IDH1 (0.38) | IDH1IDH2NOS1NOS2PDE4D | |
| SCHEMBL19687244 | 0.89 | IDH1 (0.38) | IDH1IDH2CACNA1GCACNA1HCACNA1I | |
| SCHEMBL19687241 | 0.89 | IDH1 (0.38) | IDH1IDH2PDE4DROCK2 | |
| SCHEMBL19686559 | 0.89 | IDH1 (0.37) | IDH1IDH2CACNA1GCACNA1HCACNA1I | |
| SCHEMBL19687406 | 0.89 | IDH1 (0.37) | IDH1IDH2CACNA1GCACNA1HCACNA1I | |
| SCHEMBL19686905 | 0.89 | IDH1 (0.37) | IDH1IDH2PDE4D | |
| SCHEMBL19686562 | 0.83 | IDH1 (0.36) | IDH1IDH2NOS1NOS2PDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10774064-B2 | Potassium channel modulators | CADENT THERAPEUTICS, INC. (US) | 2020-09-15 | — | — | US | disclosed |
| US-20190218200-A1 | POTASSIUM CHANNEL MODULATORS | NOVARTIS AG (CH) | 2019-07-18 | — | — | US | disclosed |
| WO-2017139697-A9 | BACTERIA ENGINEERED TO TREAT DISEASES ASSOCIATED WITH HYPERAMMONEMIA | SYNLOGIC, INC. (US) | 2017-12-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10774064-B2 | Potassium channel modulators | KCNJ11, KCNJ2, KCNJ1 | IDH1 3017/4885IDH2 2447/4885CACNA1G 66/4885 |
| US-20190218200-A1 | POTASSIUM CHANNEL MODULATORS | KCNJ11, KCNJ2, KCNJ1 | IDH1 3017/4885IDH2 2447/4885CACNA1G 66/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.