Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 4/20 | 0.44 |
| ▸ | GRIN2A | Q12879 | 4/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.44 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.44 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.44 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.44 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21452233 | 0.88 | GRIN1 (0.55) | GRIN1GRIN2ASLC6A4GRIN2DGRIN3B | |
| SCHEMBL30308901 | 0.86 | GRIN1 (0.61) | GRIN1GRIN2ASLC6A4GRIN2DGRIN3B | |
| SCHEMBL30308938 | 0.86 | GRIN1 (0.61) | GRIN1GRIN2ASLC6A4GRIN2DGRIN3B | |
| SCHEMBL19400501 | 0.86 | GRIN1 (0.61) | GRIN1GRIN2ASLC6A4GRIN2DGRIN3B | |
| SCHEMBL19688879 | 0.86 | GRIN1 (0.61) | GRIN1GRIN2ASLC6A4GRIN2DGRIN3B | |
| SCHEMBL19400462 | 0.86 | GRIN1 (0.61) | GRIN1GRIN2ASLC6A4GRIN2DGRIN3B | |
| SCHEMBL21451995 | 0.85 | GRIN1 (0.60) | GRIN1GRIN2ASLC6A4GRIN2DGRIN3B | |
| SCHEMBL26552646 | 0.79 | GRIN1 (0.40) | GRIN1GRIN2ASLC6A4GRIN2DGRIN3B | |
| SCHEMBL21452591 | 0.79 | GRIN1 (0.43) | GRIN1GRIN2ASLC6A4GRIN2DGRIN3B | |
| SCHEMBL26186990 | 0.79 | GRIN1 (0.40) | GRIN1GRIN2ASLC6A4GRIN2DGRIN3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3463323-B1 | SOLID ORAL DOSAGE FORMS OF 2R,6R-HYDROXYNORKETAMINE OR DERIVATIVES THEREOF | SMALL PHARMA LTD (GB) | 2021-10-20 | — | — | EP | disclosed |
| WO-2017208031-A1 | SOLID ORAL DOSAGE FORMS OF 2R,6R-HYDROXYNORKETAMINE OR DERIVATIVES THEREOF | SMALL PHARMA LTD (GB) | 2017-12-07 | — | — | WO | disclosed |