Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 20/20 | 0.60 |
| ▸ | IDH2 | P48735 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19692724 | 0.89 | IDH1 (0.63) | IDH1 | |
| SCHEMBL22201621 | 0.84 | IDH1 (0.65) | IDH1IDH2 | |
| SCHEMBL22201829 | 0.80 | IDH1 (0.83) | IDH1 | |
| SCHEMBL19692697 | 0.79 | IDH1 (0.76) | IDH1IDH2 | |
| SCHEMBL21400039 | 0.78 | IDH1 (0.82) | IDH1IDH2 | |
| SCHEMBL21378351 | 0.75 | IDH1 (1.00) | IDH1 | |
| SCHEMBL19700933 | 0.75 | IDH1 (1.00) | IDH1 | |
| SCHEMBL21378350 | 0.75 | IDH1 (1.00) | IDH1 | |
| SCHEMBL19700942 | 0.75 | IDH1 (1.00) | IDH1 | |
| SCHEMBL21378606 | 0.74 | IDH1 (1.00) | IDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3464281-A1 | MUTANT IDH1 INHIBITORS | Eli Lilly and Company (US) | 2019-04-10 | — | — | EP | claimed |
| WO-2017213910-A1 | MUTANT IDH1 INHIBITORS | ELI LILLY AND COMPANY (US) | 2017-12-14 | — | — | WO | claimed |
| EP-3464281-A1 | MUTANT IDH1 INHIBITORS | Eli Lilly and Company (US) | 2019-04-10 | — | — | EP | disclosed |
| WO-2017213910-A1 | MUTANT IDH1 INHIBITORS | ELI LILLY AND COMPANY (US) | 2017-12-14 | — | — | WO | disclosed |