Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 12/20 | 0.48 |
| ▸ | ACE | P12821 | 4/20 | 0.45 |
| ▸ | SYK | P43405 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | CTSS | P25774 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 1/20 | 0.41 |
| ▸ | CTSL | P07711 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | MMEL1 | Q495T6 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16942393 | 1.00 | MME (0.48) | MMEACESYKATMPPARA | |
| SCHEMBL17968662 | 0.88 | MME (0.50) | MMEACESYKATMMMEL1 | |
| SCHEMBL19705794 | 0.88 | MME (0.50) | MMEACESYKATMMMEL1 | |
| SCHEMBL19771839 | 0.87 | MME (0.45) | MMEACESYKATMMMEL1 | |
| SCHEMBL24381023 | 0.86 | MME (0.41) | MMEACEPPARACTSK | |
| SCHEMBL16932429 | 0.86 | MME (0.41) | MMEACEPPARACTSK | |
| SCHEMBL26378137 | 0.86 | MME (0.44) | MMEACESYKATMMMEL1 | |
| SCHEMBL15474326 | 0.86 | MME (0.60) | MMEACEMMEL1 | |
| SCHEMBL19696010 | 0.86 | MME (0.60) | MMEACEMMEL1 | |
| SCHEMBL19086104 | 0.86 | MME (0.60) | MMEACEMMEL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3099668-B1 | 5-BIPHENYL-4-HETEROARYLCARBONYLAMINO-PENTANOIC ACID DERIVATIVES AS NEPRILYSIN INHIBITORS | THERAVANCE BIOPHARMA R&D IP LLC (US) | 2022-05-04 | — | — | EP | disclosed |
| US-9839639-B2 | Neprilysin inhibitors | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2017-12-12 | — | — | US | disclosed |