Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 9/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | CLK2 | P49760 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1972467 | 0.94 | TOP1 (0.44) | TOP1KDM4EKCNH2ALDH1A1POLB | |
| SCHEMBL1971816 | 0.93 | TOP1 (0.42) | TOP1KDM4EKCNH2 | |
| SCHEMBL2204916 | 0.92 | TOP1 (0.46) | TOP1KDM4EKCNH2ALDH1A1POLB | |
| SCHEMBL2202810 | 0.89 | TOP1 (0.43) | TOP1KDM4EKCNH2POLB | |
| SCHEMBL1971424 | 0.88 | TOP1 (0.43) | TOP1KDM4EKCNH2ALDH1A1POLB | |
| SCHEMBL1973181 | 0.87 | TOP1 (0.38) | TOP1KDM4EALDH1A1HPGD | |
| SCHEMBL1974194 | 0.87 | TOP1 (0.41) | TOP1KDM4EKCNH2ALDH1A1POLB | |
| SCHEMBL1976421 | 0.87 | TOP1 (0.46) | TOP1KDM4EKCNH2ALDH1A1POLB | |
| SCHEMBL1974904 | 0.86 | TOP1 (0.45) | TOP1KDM4EKCNH2ALDH1A1POLB | |
| SCHEMBL1971410 | 0.86 | TOP1 (0.35) | TOP1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1994020-B1 | Substituted quinolones III | AICURIS GMBH & CO KG (DE) | 2011-06-22 | — | — | EP | disclosed |
| EP-1994020-A2 | SUBSTITUTED QUINOLONES III | AiCuris GmbH & Co. KG (DE) | 2008-11-26 | — | — | EP | disclosed |
| WO-2007090579-A2 | SUBSTITUTED QUINOLONES III | AICURIS GMBH & CO. KG (DE) | 2007-08-16 | — | — | WO | disclosed |