Sugi Predict

Sugi Predict / Compounds / SCHEMBL19698445

SCHEMBL19698445

SCHEMBL19698445

C#CCN(Cc1cccc(C(F)(F)F)c1)c1ccc(NC(=O)OCC)c(N)c1

nearest known ligand 0.72

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ KCNQ2 O43526 5/20 0.72
▸ KCNQ4 P56696 6/20 0.59
▸ KCNQ5 Q9NR82 5/20 0.56
▸ THRB P10828 1/20 0.45
▸ DHFR P00374 1/20 0.43
▸ KCNQ3 O43525 3/20 0.43
▸ TYMS P04818 1/20 0.43
▸ CETP P11597 3/20 0.41
▸ CYP1A2 P05177 1/20 0.41
▸ CYP2C8 P10632 1/20 0.41
▸ CYP2B6 P20813 1/20 0.41
▸ HDAC6 Q9UBN7 1/20 0.40
▸ HDAC3 O15379 1/20 0.39
▸ HDAC1 Q13547 1/20 0.39
▸ HDAC2 Q92769 1/20 0.39
▸ NR3C1 P04150 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30741272 1.00 KCNQ2 (0.72) KCNQ2KCNQ4KCNQ5THRBDHFR
SCHEMBL30741285 0.91 KCNQ2 (0.81) KCNQ2KCNQ4KCNQ5THRBDHFR
SCHEMBL19698444 0.91 KCNQ2 (0.81) KCNQ2KCNQ4KCNQ5THRBDHFR
SCHEMBL26974038 0.91 KCNQ2 (0.58) KCNQ2KCNQ4KCNQ5THRBKCNQ3
SCHEMBL19700186 0.90 KCNQ2 (0.79) KCNQ2KCNQ4KCNQ5KCNQ3TYMS
SCHEMBL19690507 0.89 KCNQ2 (0.55) KCNQ2KCNQ4KCNQ5DHFRTYMS
SCHEMBL30741291 0.87 KCNQ2 (0.54) KCNQ2KCNQ4KCNQ5THRBKCNQ3
SCHEMBL19698446 0.87 KCNQ2 (0.54) KCNQ2KCNQ4KCNQ5THRBKCNQ3
SCHEMBL19698584 0.86 KCNQ2 (0.54) KCNQ2KCNQ4KCNQ5THRBKCNQ3
SCHEMBL19698442 0.85 KCNQ2 (0.54) KCNQ2KCNQ4KCNQ5THRBDHFR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11858900-B2 Fluorinated 2-amino-4-(substituted amino)phenyl carbamate derivatives OCUTERRA THERAPEUTICS, INC. (US) 2024-01-02 — — US disclosed
US-11858900-B2 Fluorinated 2-amino-4-(substituted amino)phenyl carbamate derivatives OCUTERRA THERAPEUTICS, INC. (US) 2024-01-02 — — US disclosed
US-20210309612-A1 FLUORINATED 2-AMINO-4-(SUBSTITUTED AMINO)PHENYL CARBAMATE DERIVATIVES OCUTERRA THERAPEUTICS, INC. 2021-10-07 — — US disclosed
US-20170355679-A1 FLUORINATED 2-AMINO-4-(SUBSTITUTED AMINO)PHENYL CARBAMATE DERIVATIVES SCIFLUOR LIFE SCIENCES, INC. 2017-12-14 — — US disclosed
WO-2017214539-A1 FLUORINATED 2-AMINO-4-(SUBSTITUTED AMINO)PHENYL CARBAMATE DERIVATIVES SCIFLUOR LIFE SCIENCES, INC. (US) 2017-12-14 — — WO disclosed
US-20170355679-A1 FLUORINATED 2-AMINO-4-(SUBSTITUTED AMINO)PHENYL CARBAMATE DERIVATIVES SCIFLUOR LIFE SCIENCES, INC. 2017-12-14 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170355679-A1 FLUORINATED 2-AMINO-4-(SUBSTITUTED AMINO)PHENYL CARBAMATE DERIVATIVES KCNQ2, KCNQ1, KCNQ3 KCNQ2 1/4885KCNQ4 4/4885KCNQ5 7/4885
US-11858900-B2 Fluorinated 2-amino-4-(substituted amino)phenyl carbamate derivatives KCNQ2, KCNQ1, KCNQ3 KCNQ2 1/4885KCNQ4 4/4885KCNQ5 7/4885
US-20210309612-A1 FLUORINATED 2-AMINO-4-(SUBSTITUTED AMINO)PHENYL CARBAMATE DERIVATIVES KCNQ2, KCNQ1, KCNQ3 KCNQ2 1/4885KCNQ4 4/4885KCNQ5 7/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.