Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 18/20 | 0.47 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2003343 | 0.88 | NR1H4 (0.48) | NR1H4 | |
| SCHEMBL22397165 | 0.86 | POLB (0.50) | NR1H4 | |
| SCHEMBL2003480 | 0.83 | NR1H4 (0.45) | NR1H4 | |
| SCHEMBL2003625 | 0.83 | NR1H4 (0.44) | NR1H4 | |
| SCHEMBL12878991 | 0.79 | NR1H4 (0.43) | NR1H4 | |
| SCHEMBL1999960 | 0.78 | NR1H4 (0.42) | NR1H4 | |
| SCHEMBL20952007 | 0.76 | NR1H4 (0.41) | NR1H4 | |
| SCHEMBL21326421 | 0.75 | NR1H4 (0.48) | NR1H4 | |
| SCHEMBL12168753 | 0.75 | NR1H4 (0.46) | NR1H4 | |
| SCHEMBL12168769 | 0.75 | NR1H4 (0.43) | NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170355693-A1 | FXR (NR1H4) MODULATING COMPOUNDS | GILEAD SCIENCES, INC. | 2017-12-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170355693-A1 | FXR (NR1H4) MODULATING COMPOUNDS | NR1H4, NR1H2, NR1H3 | NR1H4 1/4885GPBAR1 5/4885RET 446/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.