Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MIF | P14174 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | PDE5A | O76074 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | PDE4A | P27815 | 1/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.48 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.48 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16764938 | 0.86 | MIF (0.48) | MIFMEN1ALDH1A1KMT2APDE5A | |
| SCHEMBL25332487 | 0.83 | MIF (0.48) | MIFMEN1ALDH1A1KMT2APDE5A | |
| SCHEMBL15897069 | 0.82 | MEN1 (0.48) | MIFMEN1ALDH1A1KMT2APDE5A | |
| SCHEMBL955510 | 0.81 | MIF (0.50) | MIFMEN1ALDH1A1KMT2APDE5A | |
| SCHEMBL9282684 | 0.79 | MIF (0.45) | MIFMEN1ALDH1A1KMT2APDE5A | |
| SCHEMBL11657710 | 0.78 | MIF (0.47) | MIFMEN1ALDH1A1KMT2APDE5A | |
| SCHEMBL9283378 | 0.78 | MIF (0.47) | MIFMEN1ALDH1A1KMT2APDE5A | |
| SCHEMBL16764335 | 0.77 | TSHR (0.53) | MEN1ALDH1A1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL20653898 | 0.74 | MIF (0.50) | MIFMEN1ALDH1A1KMT2APDE5A | |
| SCHEMBL1841274 | 0.74 | EGFR (0.51) | MIFMEN1ALDH1A1KMT2APDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3350180-B1 | 8-[6-[3-(AMINO)PROPOXY]-3-PYRIDYL]-1-ISOPROPYL-IMIDAZO[4,5-C]QUINOLIN-2-ONE DERIVATIVES AS SELECTIVE MODULATORS OF ATAXIA TELANGIECTASIA MUTATED (ATM) KINASE FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2020-11-11 | — | — | EP | disclosed |
| WO-2017214269-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | INFINITY PHARMACEUTICALS, INC. (US) | 2017-12-14 | — | — | WO | disclosed |