Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 20/20 | 0.78 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.78 |
| ▸ | PDE6A | P16499 | 8/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1970899 | 0.88 | PDE5A (1.00) | PDE5AKCNH2PDE6A | |
| SCHEMBL1970594 | 0.88 | PDE5A (1.00) | PDE5AKCNH2PDE6A | |
| SCHEMBL12583685 | 0.87 | PDE5A (0.84) | PDE5AKCNH2PDE6A | |
| SCHEMBL1970644 | 0.86 | PDE5A (0.84) | PDE5AKCNH2PDE6A | |
| SCHEMBL1970090 | 0.86 | PDE5A (1.00) | PDE5AKCNH2PDE6A | |
| SCHEMBL1971532 | 0.85 | PDE5A (1.00) | PDE5AKCNH2PDE6A | |
| SCHEMBL1970611 | 0.85 | PDE5A (1.00) | PDE5AKCNH2PDE6A | |
| SCHEMBL1971462 | 0.85 | PDE5A (1.00) | PDE5AKCNH2PDE6A | |
| SCHEMBL1970610 | 0.85 | PDE5A (1.00) | PDE5AKCNH2PDE6A | |
| Pf-03049423 SCHEMBL1969224 | 0.85 | PDE5A (1.00) | PDE5AKCNH2PDE6A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2013208-B1 | PYRIDIN[3,4-B]PYRAZINONES | PFIZER PROD INC (US) | 2011-06-22 | — | — | EP | claimed |
| EP-2013208-B1 | PYRIDIN[3,4-B]PYRAZINONES | PFIZER PROD INC (US) | 2011-06-22 | — | — | EP | disclosed |
| US-7902195-B2 | Pyridine [3,4-b] pyrazinones | PHARMACIA & UPJOHN COMPANY LLC (US) | 2011-03-08 | — | — | US | disclosed |