Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 5/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | MGLL | Q99685 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | CCR1 | P32246 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19701975 | 0.88 | PIK3CD (0.43) | PIK3CDNOTUMESR1KMT2AADAM10 | |
| SCHEMBL19701971 | 0.86 | PIK3CD (0.42) | PIK3CDNOTUMESR1KMT2AADAM10 | |
| SCHEMBL19701972 | 0.86 | NOTUM (0.41) | PIK3CDNOTUMESR1KMT2AADAM10 | |
| SCHEMBL19701974 | 0.86 | PIK3CD (0.48) | PIK3CDNOTUMESR1KMT2AADAM10 | |
| SCHEMBL19710656 | 0.83 | PIK3CD (0.48) | PIK3CDNOTUMHPGDALDH1A1CYP1A2 | |
| SCHEMBL19690191 | 0.82 | PIK3CD (0.47) | PIK3CDKMT2AHPGDCYP3A4ALDH1A1 | |
| SCHEMBL19701977 | 0.78 | NOTUM (0.56) | NOTUMKMT2AADAM10PANK3ALDH1A1 | |
| SCHEMBL19701998 | 0.78 | PIK3CD (0.47) | PIK3CDNOTUMKMT2AHPGDCYP3A4 | |
| SCHEMBL19701973 | 0.77 | PIK3CD (0.39) | PIK3CDNOTUMESR1KMT2AHPGD | |
| SCHEMBL19710839 | 0.73 | PIK3CD (0.44) | PIK3CDNOTUMHPGDALDH1A1MGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170355707-A1 | BICYCLIC HETEROARYL AMINE COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2017-12-14 | — | — | US | disclosed |
| US-20170355707-A1 | BICYCLIC HETEROARYL AMINE COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2017-12-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170355707-A1 | BICYCLIC HETEROARYL AMINE COMPOUNDS | PIK3R3, JAK2, JAK3 | PIK3CD 14/4885NOTUM 3221/4885ESR1 3896/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.