Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 2/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | MAP2K1 | Q02750 | 14/20 | 0.47 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.47 |
| ▸ | EGFR | P00533 | 2/20 | 0.47 |
| ▸ | SMC2 | O95347 | 1/20 | 0.47 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.47 |
| ▸ | SMC1A | Q14683 | 1/20 | 0.47 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.47 |
| ▸ | Q6ZSR9 | Q6ZSR9 | 1/20 | 0.47 |
| ▸ | BMP2K | Q9NSY1 | 1/20 | 0.47 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.38 |
| ▸ | NQO2 | P16083 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1970716 | 0.90 | CYP2C9 (0.64) | CYP2C9KCNH2CYP2C19MAP2K1MAP2K2 | |
| SCHEMBL1971814 | 0.89 | CYP2C9 (0.67) | CYP2C9KCNH2CYP2C19MAP2K1MAP2K2 | |
| SCHEMBL1969081 | 0.82 | CYP2C9 (0.80) | CYP2C9KCNH2CYP2C19MAP2K1MAP2K2 | |
| SCHEMBL1971020 | 0.80 | CYP2C9 (0.62) | CYP2C9KCNH2CYP2C19MAP2K1MAP2K2 | |
| SCHEMBL1971572 | 0.79 | CYP2C9 (0.61) | CYP2C9KCNH2CYP2C19MAP2K1MAP2K2 | |
| SCHEMBL1969541 | 0.79 | CYP2C9 (0.43) | CYP2C9KCNH2CYP2C19MAP2K1MAP2K2 | |
| SCHEMBL1975349 | 0.78 | CYP2C9 (0.80) | CYP2C9KCNH2CYP2C19MAP2K1MAP2K2 | |
| SCHEMBL1971011 | 0.78 | CYP2C9 (0.43) | CYP2C9KCNH2CYP2C19MAP2K1MAP2K2 | |
| SCHEMBL1970770 | 0.78 | CYP2C9 (0.59) | CYP2C9KCNH2CYP2C19MAP2K1MAP2K2 | |
| SCHEMBL13841979 | 0.78 | MAP2K1 (0.46) | MAP2K1MAP2K2EGFRSMC2CSNK2A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8293763-B2 | 8-anilinoimidazopyridines and their use as anti-cancer and/or anti-inflammatory agents | GENENTECH, INC. (US) | 2012-10-23 | — | — | US | disclosed |
| US-8293763-B2 | 8-anilinoimidazopyridines and their use as anti-cancer and/or anti-inflammatory agents | GENENTECH, INC. (US) | 2012-10-23 | — | — | US | disclosed |
| EP-2231662-B1 | 8-ANILINOIMIDAZOPYRIDINES AND THEIR USE AS ANTI-CANCER AND/OR ANTI-INFLAMMATORY AGENTS | GENENTECH INC (US) | 2011-06-22 | — | — | EP | disclosed |
| EP-2231662-B1 | 8-ANILINOIMIDAZOPYRIDINES AND THEIR USE AS ANTI-CANCER AND/OR ANTI-INFLAMMATORY AGENTS | GENENTECH INC (US) | 2011-06-22 | — | — | EP | disclosed |
| US-20100280063-A1 | 8-ANILINOIMIDAZOPYRIDINES AND THEIR USE AS ANTI-CANCER AND/OR ANTI-INFLAMMATORY AGENTS | GENENTECH, INC. | 2010-11-04 | — | — | US | disclosed |
| US-20100280063-A1 | 8-ANILINOIMIDAZOPYRIDINES AND THEIR USE AS ANTI-CANCER AND/OR ANTI-INFLAMMATORY AGENTS | GENENTECH, INC. | 2010-11-04 | — | — | US | disclosed |
| WO-2009085980-A1 | 8-ANILIN0IMIDAZ0PYRIDINES AND THEIR USE AS ANTI-CANCER AND/OR ANTI-INFLAMMATORY AGENTS | GENENTECH, INC. (US) | 2009-07-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100280063-A1 | 8-ANILINOIMIDAZOPYRIDINES AND THEIR USE AS ANTI-CANCER AND/OR ANTI-INFLAMMATORY AGENTS | MAP3K8, MAPK8, MAP3K1 | CYP2C9 1838/4885KCNH2 1456/4885CYP2C19 2035/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.