Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 2/20 | 0.42 |
| ▸ | STAT6 | P42226 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | AXL | P30530 | 6/20 | 0.39 |
| ▸ | TYRO3 | Q06418 | 5/20 | 0.39 |
| ▸ | MERTK | Q12866 | 4/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | WNT3A | P56704 | 1/20 | 0.39 |
| ▸ | CDK4 | P11802 | 1/20 | 0.38 |
| ▸ | CCND1 | P24385 | 1/20 | 0.38 |
| ▸ | CCND2 | P30279 | 1/20 | 0.38 |
| ▸ | CCND3 | P30281 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | WEE1 | P30291 | 2/20 | 0.38 |
| ▸ | IGF1R | P08069 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19708824 | 0.88 | WEE1 (0.43) | JAK3SYKPOLBSMN1; SMN2TYRO3 | |
| SCHEMBL19708754 | 0.83 | SRC (0.44) | SRCJAK3STAT6SYKGAA | |
| SCHEMBL21170601 | 0.76 | MAPT (0.44) | SRCJAK3SYKJAK2 | |
| SCHEMBL5998192 | 0.76 | SRC (0.47) | SRCJAK3STAT6SYKGAA | |
| SCHEMBL19708757 | 0.76 | MAPT (0.64) | SRCJAK3WNT3AJAK2 | |
| SCHEMBL19708756 | 0.74 | FYN (0.46) | SRC | |
| SCHEMBL9959309 | 0.73 | CDK5 (0.49) | AXLTYRO3MERTKCDK4HTR2C | |
| SCHEMBL5997162 | 0.72 | MAPT (0.48) | SRCJAK3SYKGAAWNT3A | |
| SCHEMBL26640375 | 0.71 | CDK4 (0.41) | JAK3SYKAXLTYRO3MERTK | |
| SCHEMBL9959904 | 0.71 | CDK2 (0.67) | SMN1; SMN2AXLTYRO3MERTKCDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3466948-B1 | FUSED PYRIMIDINOPIPERIDINE DERIVATIVE, AND MANUFACTURING METHOD AND APPLICATION THEREOF | SHANGHAI ALLIST PHARMACEUTICALS CO LTD (CN) | 2021-01-20 | — | — | EP | disclosed |
| EP-3466948-A1 | FUSED PYRIMIDINOPIPERIDINE DERIVATIVE, AND MANUFACTURING METHOD AND APPLICATION THEREOF | Shanghai Allist Pharmaceutical and Medical Technology Corporations (CN) | 2019-04-10 | — | — | EP | disclosed |
| WO-2017211216-A1 | FUSED PYRIMIDINOPIPERIDINE DERIVATIVE, AND MANUFACTURING METHOD AND APPLICATION THEREOF | 上海艾力斯医药科技有限公司 | 2017-12-14 | — | — | WO | disclosed |