Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLK2 | Q86UE8 | 13/20 | 0.68 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.68 |
| ▸ | RET | P07949 | 3/20 | 0.68 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.68 |
| ▸ | CDK1 | P06493 | 2/20 | 0.68 |
| ▸ | CDK2 | P24941 | 2/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.68 |
| ▸ | KDR | P35968 | 2/20 | 0.68 |
| ▸ | GSK3A | P49840 | 2/20 | 0.68 |
| ▸ | GSK3B | P49841 | 2/20 | 0.68 |
| ▸ | CDK7 | P50613 | 2/20 | 0.68 |
| ▸ | CDK9 | P50750 | 2/20 | 0.68 |
| ▸ | MAPT | P10636 | 2/20 | 0.68 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.68 |
| ▸ | FLT3 | P36888 | 2/20 | 0.68 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.68 |
| ▸ | PLK4 | O00444 | 1/20 | 0.68 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.68 |
| ▸ | AURKA | O14965 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9921923 | 0.84 | TLK2 (0.72) | TLK2CDK5RETPDPK1CDK1 | |
| SCHEMBL12056351 | 0.81 | TLK2 (0.67) | TLK2CDK5RETPDPK1CDK1 | |
| SCHEMBL12727794 | 0.81 | TLK2 (0.67) | TLK2CDK5RETPDPK1CDK1 | |
| SCHEMBL12056352 | 0.81 | TLK2 (0.67) | TLK2CDK5RETPDPK1CDK1 | |
| Su-9516 SCHEMBL1170686 | 0.81 | TLK2 (1.00) | TLK2CDK5RETPDPK1CDK1 | |
| SCHEMBL12064437 | 0.81 | TLK2 (0.67) | TLK2CDK5RETPDPK1CDK1 | |
| Su-9516 SCHEMBL1170687 | 0.81 | TLK2 (1.00) | TLK2CDK5RETPDPK1CDK1 | |
| SCHEMBL20401696 | 0.81 | TLK2 (0.67) | TLK2CDK5RETPDPK1CDK1 | |
| Su-9516 SCHEMBL29705821 | 0.81 | TLK2 (1.00) | TLK2CDK5RETPDPK1CDK1 | |
| SCHEMBL29476105 | 0.81 | TLK2 (1.00) | TLK2CDK5RETPDPK1CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017211946-A1 | 2-OXO-1,2-DIHYDROPYRIDINE-3-CARBOXAMIDE COMPOUNDS AND THEIR USE AS DUAL INHIBITORS OF PDK1/AURA | INTERNATIONAL SOCIETY FOR DRUG DEVELOPMENT S.R.L. (IT) | 2017-12-14 | — | — | WO | disclosed |