Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 9/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | MAP4K1 | Q92918 | 5/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.44 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | PGR | P06401 | 1/20 | 0.44 |
| ▸ | CSF1R | P07333 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | KIT | P10721 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27787175 | 0.84 | JAK2 (0.51) | JAK2CYP2C9CYP3A4CYP2C19MAP4K1 | |
| SCHEMBL16891589 | 0.83 | JAK2 (0.50) | JAK2CYP2C9CYP3A4CYP2C19MAP4K1 | |
| SCHEMBL17883509 | 0.82 | JAK2 (0.47) | JAK2CYP2C9CYP3A4CYP2C19MAP4K1 | |
| SCHEMBL1267965 | 0.82 | JAK2 (0.47) | JAK2CYP2C9CYP3A4CYP2C19MAP4K1 | |
| SCHEMBL31635964 | 0.81 | JAK2 (0.49) | JAK2CYP2C9CYP3A4CYP2C19MAP4K1 | |
| Iodide SCHEMBL17873364 | 0.81 | JAK2 (0.46) | JAK2CYP2C9CYP3A4CYP2C19MAP4K1 | |
| SCHEMBL12762846 | 0.81 | CYP3A4 (0.48) | CYP2C9CYP3A4CYP2C19MAP4K1CYP2D6 | |
| SCHEMBL12146866 | 0.81 | CYP3A4 (0.48) | CYP2C9CYP3A4CYP2C19MAP4K1ABL1 | |
| SCHEMBL23405066 | 0.80 | HTR2A (0.58) | JAK2CYP2C9CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL21920736 | 0.80 | JAK2 (0.48) | JAK2CYP2C9CYP3A4CYP2C19MAP4K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170355704-A1 | FUSED BICYCLIC COMPOUNDS FOR THE TREATMENT OF DISEASE | ABBVIE INC. | 2017-12-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170355704-A1 | FUSED BICYCLIC COMPOUNDS FOR THE TREATMENT OF DISEASE | VHL, BRDT, PAICS | JAK2 1155/4885CYP2C9 3125/4885CYP3A4 2188/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.