Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bay-1161909. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK known ✓ | P33981 | 20/20 | 0.89 |
| ▸ | KIT | P10721 | 1/20 | 0.89 |
| ▸ | MTOR | P42345 | 1/20 | 0.89 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.89 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.89 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.89 |
| ▸ | STK38 | Q15208 | 1/20 | 0.89 |
| ▸ | BRSK2 | Q8IWQ3 | 1/20 | 0.89 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.89 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.89 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.89 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bay-1161909 SCHEMBL19716256 | 1.00 | TTK (0.89) | TTKKITMTORMAPK8MAPK9 | |
| Bay-1161909 SCHEMBL19716251 | 0.99 | TTK (0.88) | TTKKITMTORMAPK8MAPK9 | |
| Bay-1161909 SCHEMBL19716252 | 0.99 | TTK (0.88) | TTKKITMTORMAPK8MAPK9 | |
| Bay-1161909 SCHEMBL15036679 | 0.94 | TTK (1.00) | TTKKITMTORMAPK8MAPK9 | |
| Bay-1161909 SCHEMBL29446169 | 0.94 | TTK (1.00) | TTKKITMTORMAPK8MAPK9 | |
| Bay-1161909 SCHEMBL19729431 | 0.94 | TTK (1.00) | TTKKITMTORMAPK8MAPK9 | |
| Bay-1161909 SCHEMBL15036597 | 0.94 | TTK (1.00) | TTKKITMTORMAPK8MAPK9 | |
| SCHEMBL15415858 | 0.87 | TTK (0.85) | TTKKITMTORMAPK8MAPK9 | |
| SCHEMBL15434339 | 0.87 | TTK (0.85) | TTKKITMTORMAPK8MAPK9 | |
| SCHEMBL15036890 | 0.87 | TTK (0.85) | TTKKITMTORMAPK8MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017216025-A1 | MPS-1 INHIBITORS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2017-12-21 | — | — | WO | disclosed |