SCHEMBL19720352

SCHEMBL19720352

CC1(C)CC(OC(=O)c2ccccc2)CC(C)(C)N1N

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.68
GAA P10253 2/20 0.64
KMT2A Q03164 3/20 0.60
MEN1 O00255 1/20 0.52
CHRNA7 P36544 2/20 0.51
HTR3E A5X5Y0 1/20 0.51
HTR3B O95264 1/20 0.51
HTR3A P46098 1/20 0.51
HTR3D Q70Z44 1/20 0.51
HTR3C Q8WXA8 1/20 0.51
ALDH1A1 P00352 1/20 0.48
ESR1 P03372 1/20 0.48
HSD17B10 Q99714 1/20 0.48
APOBEC3A P31941 1/20 0.47
APOBEC3G Q9HC16 1/20 0.47
HTT P42858 1/20 0.46
SCN1A P35498 1/20 0.46
SCN2A Q99250 1/20 0.46
SCN3A Q9NY46 1/20 0.46
CARM1 Q86X55 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19884601 0.92 TSHR (0.57) TSHRGAAKMT2AMEN1CHRNA7
SCHEMBL19884590 0.87 GAA (0.54) TSHRGAAKMT2AMEN1ALDH1A1
SCHEMBL19884630 0.87 TSHR (0.52) TSHRGAAKMT2AMEN1CHRNA7
SCHEMBL243559 0.86 TSHR (0.70) TSHRGAAKMT2AMEN1CHRNA7
SCHEMBL294975 0.86 TSHR (0.70) TSHRGAAKMT2AMEN1CHRNA7
SCHEMBL51072 0.86 TSHR (0.70) TSHRGAAKMT2AMEN1CHRNA7
SCHEMBL10525245 0.84 TSHR (0.64) TSHRGAAKMT2AMEN1CHRNA7
SCHEMBL19720327 0.84 TSHR (0.50) TSHRGAAKMT2AMEN1ALDH1A1
SCHEMBL19720339 0.84 TSHR (0.50) TSHRGAAKMT2AMEN1ALDH1A1
SCHEMBL7533362 0.84 TSHR (0.75) TSHRGAAKMT2AMEN1CHRNA7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2855630-B1 LIQUID CRYSTAL MEDIUM AND LIQUID CRYSTAL DISPLAY MERCK PATENT GMBH (DE) 2017-12-20 EP disclosed