Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 4/20 | 0.49 |
| ▸ | NOS3 | P29474 | 4/20 | 0.47 |
| ▸ | NOS1 | P29475 | 4/20 | 0.47 |
| ▸ | NOS2 | P35228 | 4/20 | 0.47 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.47 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1411148 | 1.00 | MAPK14 (0.49) | MAPK14NOS3NOS1NOS2TAS1R3 | |
| SCHEMBL1411146 | 1.00 | MAPK14 (0.49) | MAPK14NOS3NOS1NOS2TAS1R3 | |
| SCHEMBL1411144 | 1.00 | MAPK14 (0.49) | MAPK14NOS3NOS1NOS2TAS1R3 | |
| SCHEMBL1411238 | 0.89 | NR1H4 (0.47) | MAPK14NOS3NOS1NOS2TAS1R3 | |
| SCHEMBL1411239 | 0.89 | NR1H4 (0.47) | MAPK14NOS3NOS1NOS2TAS1R3 | |
| SCHEMBL1411240 | 0.89 | NR1H4 (0.47) | MAPK14NOS3NOS1NOS2TAS1R3 | |
| SCHEMBL17752931 | 0.88 | MAPK14 (0.46) | MAPK14NOS3NOS1NOS2TAS1R3 | |
| SCHEMBL1410862 | 0.85 | HDAC6 (0.51) | NOS3NOS1NOS2TAS1R3TAS1R1 | |
| SCHEMBL1410865 | 0.85 | HDAC6 (0.51) | NOS3NOS1NOS2TAS1R3TAS1R1 | |
| SCHEMBL1410866 | 0.85 | HDAC6 (0.51) | NOS3NOS1NOS2TAS1R3TAS1R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2069291-B1 | HDAC INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2017-12-20 | — | — | EP | disclosed |