Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 17/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 15/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 14/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.51 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.51 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 15/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.41 |
| ▸ | KDM1A | O60341 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | MEF2D | Q14814 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1411190 | 1.00 | HDAC1 (0.51) | HDAC1HDAC3HDAC8HDAC6HDAC4 | |
| SCHEMBL1411193 | 1.00 | HDAC1 (0.51) | HDAC1HDAC3HDAC8HDAC6HDAC4 | |
| SCHEMBL1410711 | 0.97 | HDAC3 (0.48) | HDAC1HDAC3HDAC8HDAC6HDAC4 | |
| SCHEMBL1411564 | 0.97 | HDAC3 (0.48) | HDAC1HDAC3HDAC8HDAC6HDAC4 | |
| SCHEMBL1411557 | 0.97 | HDAC3 (0.48) | HDAC1HDAC3HDAC8HDAC6HDAC4 | |
| SCHEMBL1410714 | 0.97 | HDAC3 (0.48) | HDAC1HDAC3HDAC8HDAC6HDAC4 | |
| SCHEMBL1410971 | 0.93 | HDAC4 (0.51) | HDAC1HDAC3HDAC8HDAC6HDAC4 | |
| SCHEMBL1410977 | 0.93 | HDAC4 (0.51) | HDAC1HDAC3HDAC8HDAC6HDAC4 | |
| SCHEMBL12810013 | 0.84 | MAPK14 (0.38) | HDAC1HDAC3HDAC8HDAC6HDAC4 | |
| SCHEMBL8203850 | 0.84 | MAPK14 (0.38) | HDAC1HDAC3HDAC8HDAC6HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2069291-B1 | HDAC INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2017-12-20 | — | — | EP | disclosed |