Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 11/20 | 0.53 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.37 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2631928 | 0.84 | PDPK1 (0.52) | PDPK1P2RY14PDE10AP2RX7PTGER4 | |
| SCHEMBL2621698 | 0.83 | PDPK1 (0.61) | PDPK1PDE10A | |
| SCHEMBL19723059 | 0.79 | PDPK1 (0.57) | PDPK1P2RY14 | |
| SCHEMBL2632134 | 0.74 | PDPK1 (0.80) | PDPK1PDE10A | |
| SCHEMBL12182671 | 0.74 | PDPK1 (0.48) | PDPK1P2RY14PDE10AP2RX7 | |
| SCHEMBL2621699 | 0.73 | PDPK1 (0.58) | PDPK1 | |
| SCHEMBL2621658 | 0.73 | PDPK1 (0.50) | PDPK1P2RY14P2RX7PTGER4 | |
| SCHEMBL2621645 | 0.73 | GAA (0.51) | PDPK1P2RY14P2RX7FGFR1FGFR4 | |
| SCHEMBL13534298 | 0.72 | PDPK1 (0.51) | PDPK1P2RY14P2RX7FGFR1FGFR4 | |
| SCHEMBL2120820 | 0.70 | PDPK1 (1.00) | PDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2560967-B1 | Heterocyclic carboxylic acid amides as PDK1 inihibitors | BOEHRINGER INGELHEIM INT (DE) | 2017-12-20 | — | — | EP | disclosed |