Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.40 |
| ▸ | EGFR | P00533 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.34 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL382421 | 0.83 | LRRK2 (0.53) | ALDH1A1HPGDLRRK2EGFRMAPT | |
| SCHEMBL883283 | 0.81 | LRRK2 (0.67) | LRRK2 | |
| SCHEMBL875542 | 0.77 | LRRK2 (0.48) | LRRK2 | |
| SCHEMBL16517352 | 0.74 | LRRK2 (0.65) | KDM4ESMN1; SMN2LRRK2PARP1MAPK8 | |
| SCHEMBL21451895 | 0.72 | KDM4E (0.35) | KDM4ESMN1; SMN2ALDH1A1HSD17B10HPGD | |
| SCHEMBL3762186 | 0.72 | LRRK2 (0.52) | LRRK2EGFRPARP1 | |
| SCHEMBL3035725 | 0.71 | KDM4E (0.54) | KDM4ESMN1; SMN2ALDH1A1HSD17B10HPGD | |
| SCHEMBL19564547 | 0.71 | LRRK2 (0.53) | LRRK2EGFR | |
| SCHEMBL16517436 | 0.71 | LRRK2 (0.48) | KDM4ELRRK2MAPK8 | |
| SCHEMBL3774692 | 0.70 | LRRK2 (0.48) | KDM4ESMN1; SMN2LRRK2PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017215600-A1 | SUBSTITUTED TRICYCLIC HERTEOCYCLIC COMPOUNDS AND USE THEREOF | SUZHOU YABAO PHARMACEUTICAL R&D CO., LTD. (CN) | 2017-12-21 | — | — | WO | disclosed |