Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 10/20 | 1.00 |
| ▸ | FGFR1 | P11362 | 8/20 | 1.00 |
| ▸ | FGFR2 | P21802 | 12/20 | 0.73 |
| ▸ | EGFR | P00533 | 4/20 | 0.66 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.65 |
| ▸ | KDR | P35968 | 3/20 | 0.65 |
| ▸ | SRC | P12931 | 2/20 | 0.63 |
| ▸ | ABL1 | P00519 | 1/20 | 0.63 |
| ▸ | ABL2 | P42684 | 1/20 | 0.63 |
| ▸ | BTK | Q06187 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17902988 | 1.00 | FGFR4 (1.00) | FGFR4FGFR1FGFR2EGFRFGFR3 | |
| SCHEMBL19731399 | 0.89 | FGFR4 (0.80) | FGFR4FGFR1FGFR2EGFRFGFR3 | |
| SCHEMBL14706446 | 0.86 | FGFR4 (0.75) | FGFR4FGFR1FGFR2EGFRFGFR3 | |
| SCHEMBL17772367 | 0.85 | FGFR4 (0.74) | FGFR4FGFR1FGFR2EGFRFGFR3 | |
| SCHEMBL14706440 | 0.85 | FGFR4 (0.74) | FGFR4FGFR1FGFR2EGFRFGFR3 | |
| SCHEMBL15345802 | 0.85 | FGFR2 (1.00) | FGFR4FGFR1FGFR2FGFR3KDR | |
| SCHEMBL15345801 | 0.85 | FGFR2 (1.00) | FGFR4FGFR1FGFR2FGFR3KDR | |
| SCHEMBL14706441 | 0.85 | FGFR4 (0.73) | FGFR4FGFR1FGFR2EGFRFGFR3 | |
| SCHEMBL17772365 | 0.84 | FGFR2 (0.77) | FGFR4FGFR1FGFR2EGFRFGFR3 | |
| SCHEMBL17772372 | 0.84 | FGFR1 (0.72) | FGFR4FGFR1FGFR2EGFRFGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3486244-A1 | NEW COMPOUND HAVING FGFR INHIBITORY ACTIVITY AND PREPARATION AND APPLICATION THEREOF | Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) | 2019-05-22 | — | — | EP | disclosed |
| EP-3486244-A1 | NEW COMPOUND HAVING FGFR INHIBITORY ACTIVITY AND PREPARATION AND APPLICATION THEREOF | Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) | 2019-05-22 | — | — | EP | disclosed |
| WO-2017215485-A1 | NEW COMPOUND HAVING FGFR INHIBITORY ACTIVITY AND PREPARATION AND APPLICATION THEREOF | 中国科学院上海药物研究所 | 2017-12-21 | — | — | WO | disclosed |