Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 16/20 | 0.66 |
| ▸ | EGFR | P00533 | 3/20 | 0.66 |
| ▸ | ABL1 | P00519 | 2/20 | 0.61 |
| ▸ | ABL2 | P42684 | 2/20 | 0.61 |
| ▸ | BTK | Q06187 | 2/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.46 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19731457 | 0.94 | SRC (0.73) | SRCEGFRABL1ABL2FGFR1 | |
| SCHEMBL19731356 | 0.90 | SRC (0.61) | SRCEGFRABL1ABL2 | |
| SCHEMBL14637043 | 0.89 | SRC (0.65) | SRCEGFRABL1ABL2BTK | |
| SCHEMBL15913719 | 0.89 | SRC (0.65) | SRCEGFRABL1ABL2BTK | |
| SCHEMBL30806175 | 0.89 | SRC (0.65) | SRCEGFRABL1ABL2BTK | |
| SCHEMBL13858167 | 0.89 | SRC (0.65) | SRCEGFRABL1ABL2BTK | |
| SCHEMBL13857886 | 0.89 | SRC (0.65) | SRCEGFRABL1ABL2BTK | |
| SCHEMBL28627629 | 0.89 | SRC (0.66) | SRCEGFRABL1ABL2BTK | |
| SCHEMBL29926654 | 0.89 | SRC (0.66) | SRCEGFRABL1ABL2BTK | |
| SCHEMBL28627632 | 0.89 | SRC (0.66) | SRCEGFRABL1ABL2BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3486244-A1 | NEW COMPOUND HAVING FGFR INHIBITORY ACTIVITY AND PREPARATION AND APPLICATION THEREOF | Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) | 2019-05-22 | — | — | EP | disclosed |
| WO-2017215485-A1 | NEW COMPOUND HAVING FGFR INHIBITORY ACTIVITY AND PREPARATION AND APPLICATION THEREOF | 中国科学院上海药物研究所 | 2017-12-21 | — | — | WO | disclosed |